Biocompatible Polypyrrole colloids for biocomposites

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F70883521%3A28610%2F24%3A63588559" target="_blank" >RIV/70883521:28610/24:63588559 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Biocompatible Polypyrrole colloids for biocomposites

Popis výsledku v původním jazyce

Polypyrrole (PPy) has great potential for biomedical applications. It can be used as a material for electrostimulation and electrosensing. It is even capable of influencing the immune response. However, its usability is limited by its poor processability and brittleness. Therefore, a colloidal form of PPy is the optimal choice for incorporation into composite materials for biomedical applications. Here, colloidal PPy has been prepared using 1, 2, and 4 wt. % of PVP as a stabilizer. The PPy/PVP _ 1 % and PPy/PVP _2% colloids showed excellent stability under physiological conditions, even after long-term storage. All samples showed low cytotoxicity, with no cytotoxic effects observed for doses of more than 200 µg/mL. Furthermore, even at much lower concentrations, the samples showed strong antioxidant effects and irnmunomodulatory activity based on the scavenging of reactive oxygen species produced by neutrophils and the reduction of IL-6 and NO production by macrophages. The best antibacterial activity was observed for the PPy/PVP _ 2% sample. The minimum inhibitory concentration was 234 µg/mL against S. aureus and E. coli. Compared to the colloidal ANI prepared under the same conditions, these colloidal PPy/PVP also showed lower cytotoxicity together with better antibacterial activity. Overall, the results indicate that the colloidal form of PPy has great potential in biomedical applications, such as hydrogel-based composites.

Název v anglickém jazyce

Biocompatible Polypyrrole colloids for biocomposites

Popis výsledku anglicky

Polypyrrole (PPy) has great potential for biomedical applications. It can be used as a material for electrostimulation and electrosensing. It is even capable of influencing the immune response. However, its usability is limited by its poor processability and brittleness. Therefore, a colloidal form of PPy is the optimal choice for incorporation into composite materials for biomedical applications. Here, colloidal PPy has been prepared using 1, 2, and 4 wt. % of PVP as a stabilizer. The PPy/PVP _ 1 % and PPy/PVP _2% colloids showed excellent stability under physiological conditions, even after long-term storage. All samples showed low cytotoxicity, with no cytotoxic effects observed for doses of more than 200 µg/mL. Furthermore, even at much lower concentrations, the samples showed strong antioxidant effects and irnmunomodulatory activity based on the scavenging of reactive oxygen species produced by neutrophils and the reduction of IL-6 and NO production by macrophages. The best antibacterial activity was observed for the PPy/PVP _ 2% sample. The minimum inhibitory concentration was 234 µg/mL against S. aureus and E. coli. Compared to the colloidal ANI prepared under the same conditions, these colloidal PPy/PVP also showed lower cytotoxicity together with better antibacterial activity. Overall, the results indicate that the colloidal form of PPy has great potential in biomedical applications, such as hydrogel-based composites.

Druh

O - Ostatní výsledky

CEP obor

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OECD FORD obor

30404 - Biomaterials (as related to medical implants, devices, sensors)

Projekt

<a href="/cs/project/GA23-07425S" target="_blank" >GA23-07425S: Anisotropní a elektricky vodivé biomateriály</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2024

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů