Molecular Radiation Biology

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081707%3A_____%2F23%3A00601476" target="_blank" >RIV/68081707:_____/23:00601476 - isvavai.cz</a>

Výsledek na webu

<a href="https://link.springer.com/book/10.1007/978-3-031-18810-7" target="_blank" >https://link.springer.com/book/10.1007/978-3-031-18810-7</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/978-3-031-18810-7_3" target="_blank" >10.1007/978-3-031-18810-7_3</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Molecular Radiation Biology

Popis výsledku v původním jazyce

Chapter Objectives • To gain familiarity with biomolecules that undergo radiolysis after ionizing radiation (IR) and to learn about some of the damaged products and the expected biological consequences • To understand how IR influences various DNA repair mechanisms, cell cycle phases, and cell death mechanisms as well as associated signaling cascades that are involved • To get knowledge on higher order chromatin organization and its connection to DNA damage repair • To be able to distinguish between cell survival and cell viability and understand different in vitro and in vivo assays used to evaluate clonogenic capacity • To understand chromosomal aberrations including chromosomal translocations in different cell cycle phases, formation of micronuclei, radiation-induced foci, and their dependence on the type of the incidental radiation as well as to acknowledge the health risks of such cellular damages • To get familiar with mechanisms of oxidative stress, telomeres/senescence, and immunity in the context of cancer biology and/or radiation response • To get acquainted with the types and underlying mechanisms of cellular hyper-radiosensitivity • To describe how radiation resistance can be induced by external factors such as hypoxia and previous low-dose exposure or as part of the tumor cell evolution • To get knowledge on the role of epigenetic factors, e.g., various types of RNAs, extracellular vesicles, as well as DNA methylation, histone modification, and gene expression in the cellular radiation response • To define signatures of radiation response comprised of changes at gene transcription level and their biological consequences • To become acquainted with CRISPR-CAS9 genome editing system and its application in molecular biology science as well as in DNA DSB repair analyses

Název v anglickém jazyce

Molecular Radiation Biology

Popis výsledku anglicky

Chapter Objectives • To gain familiarity with biomolecules that undergo radiolysis after ionizing radiation (IR) and to learn about some of the damaged products and the expected biological consequences • To understand how IR influences various DNA repair mechanisms, cell cycle phases, and cell death mechanisms as well as associated signaling cascades that are involved • To get knowledge on higher order chromatin organization and its connection to DNA damage repair • To be able to distinguish between cell survival and cell viability and understand different in vitro and in vivo assays used to evaluate clonogenic capacity • To understand chromosomal aberrations including chromosomal translocations in different cell cycle phases, formation of micronuclei, radiation-induced foci, and their dependence on the type of the incidental radiation as well as to acknowledge the health risks of such cellular damages • To get familiar with mechanisms of oxidative stress, telomeres/senescence, and immunity in the context of cancer biology and/or radiation response • To get acquainted with the types and underlying mechanisms of cellular hyper-radiosensitivity • To describe how radiation resistance can be induced by external factors such as hypoxia and previous low-dose exposure or as part of the tumor cell evolution • To get knowledge on the role of epigenetic factors, e.g., various types of RNAs, extracellular vesicles, as well as DNA methylation, histone modification, and gene expression in the cellular radiation response • To define signatures of radiation response comprised of changes at gene transcription level and their biological consequences • To become acquainted with CRISPR-CAS9 genome editing system and its application in molecular biology science as well as in DNA DSB repair analyses

Druh

C - Kapitola v odborné knize

CEP obor

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OECD FORD obor

30224 - Radiology, nuclear medicine and medical imaging

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2023

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název knihy nebo sborníku

Radiobiology Textbook

ISBN

978-3-031-18809-1

Počet stran výsledku

107

Strana od-do

83-189

Počet stran knihy

687

Název nakladatele

Springer

Místo vydání

Švýcarsko

Kód UT WoS kapitoly

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