Biventricular pacing optimization by means of the dyssynchrony parameter

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081731%3A_____%2F16%3A00474791" target="_blank" >RIV/68081731:_____/16:00474791 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.22489/CinC.2016.051-263" target="_blank" >http://dx.doi.org/10.22489/CinC.2016.051-263</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.22489/CinC.2016.051-263" target="_blank" >10.22489/CinC.2016.051-263</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Biventricular pacing optimization by means of the dyssynchrony parameter

Popis výsledku v původním jazyce

To improve Cardiac Resynchronization Therapy (CRT), different interventricular delay (VVD) settings can be used. However, relatively small VVD induced hemodynamic changes cannot be measured by standard echocardiographic methods. The QRS complex duration (QRSd) is mostly the main criterion. Here we introduce a new dyssynchrony parameter (DYS) that is able to more accurately detect improved electrical synchrony. Methods: 12-lead 5 kHz ECG during 3-10 minute rest period was measured in 46 patients with CRT OFF and CRT ON with VVD 0 ms (CRT0) and -20 ms (CRT20). We detected QRSd and the dyssynchrony parameter DYS as the time difference between 500-1000 Hz averaged envelopes positions in the V1 and V6 leads in the QRS complex region. Results: 32 of 46 patients had a positive CRT response manifested by QRSd shortening and a DYS decrease. 28 of 32 patients had a positive LV pre-excitation effect: additional QRSd shortening of 4.7+/-.9 ms and a DYS decrease of 12.6+/-7.5 ms. The correlation coefficient of QRSd and DYS changes (CRT 0 vs CRT 20) was 0.23 and indicates information diversity. The DYS parameter differs from QRSd and provides a significantly higher response to VVdelay changes (p <, 0.001).

Název v anglickém jazyce

Biventricular pacing optimization by means of the dyssynchrony parameter

Popis výsledku anglicky

To improve Cardiac Resynchronization Therapy (CRT), different interventricular delay (VVD) settings can be used. However, relatively small VVD induced hemodynamic changes cannot be measured by standard echocardiographic methods. The QRS complex duration (QRSd) is mostly the main criterion. Here we introduce a new dyssynchrony parameter (DYS) that is able to more accurately detect improved electrical synchrony. Methods: 12-lead 5 kHz ECG during 3-10 minute rest period was measured in 46 patients with CRT OFF and CRT ON with VVD 0 ms (CRT0) and -20 ms (CRT20). We detected QRSd and the dyssynchrony parameter DYS as the time difference between 500-1000 Hz averaged envelopes positions in the V1 and V6 leads in the QRS complex region. Results: 32 of 46 patients had a positive CRT response manifested by QRSd shortening and a DYS decrease. 28 of 32 patients had a positive LV pre-excitation effect: additional QRSd shortening of 4.7+/-.9 ms and a DYS decrease of 12.6+/-7.5 ms. The correlation coefficient of QRSd and DYS changes (CRT 0 vs CRT 20) was 0.23 and indicates information diversity. The DYS parameter differs from QRSd and provides a significantly higher response to VVdelay changes (p <, 0.001).

Druh

D - Stať ve sborníku

CEP obor

—

OECD FORD obor

20601 - Medical engineering

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2016

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název statě ve sborníku

Computing in Cardiology (CinC) 2016

ISBN

978-1-5090-0896-4

ISSN

2325-8861

e-ISSN

—

Počet stran výsledku

4

Strana od-do

165-168

Název nakladatele

Computing in Cardiology

Místo vydání

Vencouver

Místo konání akce

Vencouver

Datum konání akce

11. 9. 2016

Typ akce podle státní příslušnosti

WRD - Celosvětová akce

Kód UT WoS článku

000405710400042