Factors affecting the 27K DNA methylation pattern in asthmatic and healthy children from locations with various environments

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378041%3A_____%2F13%3A00395370" target="_blank" >RIV/68378041:_____/13:00395370 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1016/j.mrfmmm.2013.02.003" target="_blank" >http://dx.doi.org/10.1016/j.mrfmmm.2013.02.003</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.mrfmmm.2013.02.003" target="_blank" >10.1016/j.mrfmmm.2013.02.003</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Factors affecting the 27K DNA methylation pattern in asthmatic and healthy children from locations with various environments

Popis výsledku v původním jazyce

Gene expression levels are significantly regulated by DNA methylation. In this study the methylation profiles in children (7-15 years) with and without asthma from two regions with different levels of air pollution (a highly polluted Ostrava region and acontrol Prachatice region) were studied. Results demonstrate a significant impact of different environmental conditions on the DNA methylation patterns of children from the two regions. No difference in DNA methylation patterns was found between children with and without bronchial asthma in individual locations, but patterns in both asthmatic and healthy children differed between Ostrava and Prachatice. Further, differences in DNA methylation pattern depending on gender and urinary cotinine levels wereobserved. Other factors including lenght of gestation, birth weight and lenght of full breastfeeding are suggested as possible factors that can impact the DNA methylation pattern in future life.

Název v anglickém jazyce

Factors affecting the 27K DNA methylation pattern in asthmatic and healthy children from locations with various environments

Popis výsledku anglicky

Gene expression levels are significantly regulated by DNA methylation. In this study the methylation profiles in children (7-15 years) with and without asthma from two regions with different levels of air pollution (a highly polluted Ostrava region and acontrol Prachatice region) were studied. Results demonstrate a significant impact of different environmental conditions on the DNA methylation patterns of children from the two regions. No difference in DNA methylation patterns was found between children with and without bronchial asthma in individual locations, but patterns in both asthmatic and healthy children differed between Ostrava and Prachatice. Further, differences in DNA methylation pattern depending on gender and urinary cotinine levels wereobserved. Other factors including lenght of gestation, birth weight and lenght of full breastfeeding are suggested as possible factors that can impact the DNA methylation pattern in future life.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

DN - Vliv životního prostředí na zdraví

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2013

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis

ISSN

0027-5107

e-ISSN

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Svazek periodika

741-742

Číslo periodika v rámci svazku

January

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

9

Strana od-do

18-26

Kód UT WoS článku

000318456400003

EID výsledku v databázi Scopus

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