Chapter Six ? Mechanisms of Fast Desensitization of GABAB

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378041%3A_____%2F15%3A00458030" target="_blank" >RIV/68378041:_____/15:00458030 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1016/bs.apha.2014.11.004" target="_blank" >http://dx.doi.org/10.1016/bs.apha.2014.11.004</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/bs.apha.2014.11.004" target="_blank" >10.1016/bs.apha.2014.11.004</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Chapter Six ? Mechanisms of Fast Desensitization of GABAB

Popis výsledku v původním jazyce

GABAB receptors (GABABRs) regulate the excitability of most neurons in the central nervous system by modulating the activity of enzymes and ion channels. In the sustained presence of the neurotransmitter ?-aminobutyric acid, GABABRs exhibit a time-dependent decrease in the receptor response?a phenomenon referred to as homologous desensitization. Desensitization prevents excessive receptor influences on neuronal activity. Much work focused on the mechanisms of GABABR desensitization that operate at the receptor and control receptor expression at the plasma membrane. Over the past few years, it became apparent that GABABRs additionally evolved mechanisms for faster desensitization. These mechanisms operate at the G protein rather than at the receptor andinhibit G protein signaling within seconds of agonist exposure. The mechanisms for fast desensitization are ideally suited to regulate receptor-activated ion channel responses, which influence neuronal activity on a faster timescale than

Název v anglickém jazyce

Chapter Six ? Mechanisms of Fast Desensitization of GABAB

Popis výsledku anglicky

GABAB receptors (GABABRs) regulate the excitability of most neurons in the central nervous system by modulating the activity of enzymes and ion channels. In the sustained presence of the neurotransmitter ?-aminobutyric acid, GABABRs exhibit a time-dependent decrease in the receptor response?a phenomenon referred to as homologous desensitization. Desensitization prevents excessive receptor influences on neuronal activity. Much work focused on the mechanisms of GABABR desensitization that operate at the receptor and control receptor expression at the plasma membrane. Over the past few years, it became apparent that GABABRs additionally evolved mechanisms for faster desensitization. These mechanisms operate at the G protein rather than at the receptor andinhibit G protein signaling within seconds of agonist exposure. The mechanisms for fast desensitization are ideally suited to regulate receptor-activated ion channel responses, which influence neuronal activity on a faster timescale than

Druh

C - Kapitola v odborné knize

CEP obor

FP - Ostatní lékařské obory

OECD FORD obor

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Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název knihy nebo sborníku

Diversity and Functions of GABA Receptors: A Tribute to Hanns Möhler

ISBN

978-0-12-802658-8

Počet stran výsledku

21

Strana od-do

145-165

Počet stran knihy

270

Název nakladatele

Academic Press

Místo vydání

New York

Kód UT WoS kapitoly

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