Melanocytes and Pigmentation in Tissue Engineering

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378041%3A_____%2F17%3A00490702" target="_blank" >RIV/68378041:_____/17:00490702 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Melanocytes and Pigmentation in Tissue Engineering

Popis výsledku v původním jazyce

Skin is the largest organ of human body, representing a functional barrier against the external environment. In case of injury, the barrier function is disrupted and human body becomes vulnerable. Skin tissue engineering focuses on restoration of skin using proper stimuli. However, natural-looking pigmentation remains an issue. The aim of this study was to investigate the effect of growth factors on melanocyte proliferation and melanin synthesis. Epidermal growth factor, hepatocyte growth factor and platelet-derived growth factor-AA were added to cell culture media at concentrations of 0 ng/mL to 40 ng/mL, and their effect on melanocytes was assessed. The data did not show any statistically significant effect on melanocyte proliferation. However, in melanin synthesis, pronounced dose-dependent effect was observed, with hepatocyte growth factor stimulating melanin synthesis in lower concentrations and platelet-derived growth factor AA in higher concentrations. These findings indicate suitability of growth factors for stimulation of pigmentation in tissue engineering.

Název v anglickém jazyce

Melanocytes and Pigmentation in Tissue Engineering

Popis výsledku anglicky

Skin is the largest organ of human body, representing a functional barrier against the external environment. In case of injury, the barrier function is disrupted and human body becomes vulnerable. Skin tissue engineering focuses on restoration of skin using proper stimuli. However, natural-looking pigmentation remains an issue. The aim of this study was to investigate the effect of growth factors on melanocyte proliferation and melanin synthesis. Epidermal growth factor, hepatocyte growth factor and platelet-derived growth factor-AA were added to cell culture media at concentrations of 0 ng/mL to 40 ng/mL, and their effect on melanocytes was assessed. The data did not show any statistically significant effect on melanocyte proliferation. However, in melanin synthesis, pronounced dose-dependent effect was observed, with hepatocyte growth factor stimulating melanin synthesis in lower concentrations and platelet-derived growth factor AA in higher concentrations. These findings indicate suitability of growth factors for stimulation of pigmentation in tissue engineering.

Druh

C - Kapitola v odborné knize

CEP obor

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OECD FORD obor

20903 - Bioproducts (products that are manufactured using biological material as feedstock) biomaterials, bioplastics, biofuels, bioderived bulk and fine chemicals, bio-derived novel materials

Projekt

<a href="/cs/project/LO1508" target="_blank" >LO1508: Genomika a proteomika při studiu mechanismů biologických účinků vyráběných nanočástic</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2017

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název knihy nebo sborníku

Nanomaterials in Biomedical research

ISBN

978-80-906655-5-2

Počet stran výsledku

5

Strana od-do

40-44

Počet stran knihy

140

Název nakladatele

Proxima Tisk, s.r.o.

Místo vydání

Praha 3

Kód UT WoS kapitoly

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