Bio-inspired nanoporous scaffold: electrospun hybrid fibers based on self-assembled block copolymer mineralized with inorganic nanoparticles for bone tissue engineering

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378041%3A_____%2F24%3A00581666" target="_blank" >RIV/68378041:_____/24:00581666 - isvavai.cz</a>

Výsledek na webu

<a href="https://www.tandfonline.com/doi/full/10.1080/00914037.2023.2243369" target="_blank" >https://www.tandfonline.com/doi/full/10.1080/00914037.2023.2243369</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1080/00914037.2023.2243369" target="_blank" >10.1080/00914037.2023.2243369</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Bio-inspired nanoporous scaffold: electrospun hybrid fibers based on self-assembled block copolymer mineralized with inorganic nanoparticles for bone tissue engineering

Popis výsledku v původním jazyce

Mineralized, bio-inspired nanofibrous scaffolds with controllable architecture and capable of mimicking essential characteristics of bone extracellular matrix at the micro- and nanoscale offer a promising strategy to restore functions or elicit favorable responses for bone tissue regeneration and repair. In this study, a simple approach to fabricate a hybrid scaffold with porous fibers for bone tissue engineering is presented. Non-woven multifunctional nano- and microfibers were fabricated using a block copolymer of poly(e-caprolactone) (PCL) and poly(lactic acid) (PLA) (PL-b-CL) as a matrix and hydroxyapatite (HA) as a functional agent, dissolved in a binary solvent mixture. Physicochemical and thermal characterization as well as biocompatibility analyses were carried out using SaOS-2 cells. The results showed fibers with highly porous surfaces whose pore diameters range in the nanometer scale and all scaffolds exhibited hydrophobicity. HA-modified scaffolds significantly improved cell metabolic activity and proliferation as compared to pristine scaffolds. The biodegradable and biocompatible scaffolds proposed in this study carry great potential for various biomedical applications and in the future, it is expected that they can be used for controlled drug delivery by incorporating growth factors, proteins, or drugs to reduce the inflammatory response and/or to promote bone repair.

Název v anglickém jazyce

Bio-inspired nanoporous scaffold: electrospun hybrid fibers based on self-assembled block copolymer mineralized with inorganic nanoparticles for bone tissue engineering

Popis výsledku anglicky

Mineralized, bio-inspired nanofibrous scaffolds with controllable architecture and capable of mimicking essential characteristics of bone extracellular matrix at the micro- and nanoscale offer a promising strategy to restore functions or elicit favorable responses for bone tissue regeneration and repair. In this study, a simple approach to fabricate a hybrid scaffold with porous fibers for bone tissue engineering is presented. Non-woven multifunctional nano- and microfibers were fabricated using a block copolymer of poly(e-caprolactone) (PCL) and poly(lactic acid) (PLA) (PL-b-CL) as a matrix and hydroxyapatite (HA) as a functional agent, dissolved in a binary solvent mixture. Physicochemical and thermal characterization as well as biocompatibility analyses were carried out using SaOS-2 cells. The results showed fibers with highly porous surfaces whose pore diameters range in the nanometer scale and all scaffolds exhibited hydrophobicity. HA-modified scaffolds significantly improved cell metabolic activity and proliferation as compared to pristine scaffolds. The biodegradable and biocompatible scaffolds proposed in this study carry great potential for various biomedical applications and in the future, it is expected that they can be used for controlled drug delivery by incorporating growth factors, proteins, or drugs to reduce the inflammatory response and/or to promote bone repair.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30404 - Biomaterials (as related to medical implants, devices, sensors)

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2024

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

International Journal of Polymeric Materials and Polymeric Biomaterials

ISSN

0091-4037

e-ISSN

1563-535X

Svazek periodika

73

Číslo periodika v rámci svazku

12

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

14

Strana od-do

1054-1067

Kód UT WoS článku

001061395400001

EID výsledku v databázi Scopus

2-s2.0-85169807589