Nové porfyrinové deriváty se silným fotodynamickým protinádorovým účinkem: rozdílná efektivita mono- a bis-cyklodextrinových derivátů in vitro a in vivo

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F06%3A00045264" target="_blank" >RIV/68378050:_____/06:00045264 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11110/06:00005272

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Novel porphyrin conjugates with a potent photodynamic antitumor effect: differential efficacy of mono- and bis-beta-cyclodextrin derivatives in vitro and in vivo

Popis výsledku v původním jazyce

Photodynamic therapy employs systemic administration of a tumor-localizing photosensitizer followed by local irradiation of the tumor with visible light. The interaction between the excited photosensitizer and endogenous molecular oxygen generates reactive oxygen species, resulting in a cascade of biochemical events leading to cancer cell death. In the present study we investigated photosensitizing properties of two novel mono- and bis-cyclodextrin tetrakis (pentafluorophenyl) porphyrin derivatives in several tumor cell lines and in BALB/c mice bearing transplanted mammary carcinoma. Although both studied porphyrins exhibited similar intracellular localization, the mono-cyclodextrin derivative produced a stronger in vitro phototoxic effect than the bis-cyclodextrin derivative. In vivo, however, the efficacy of the bis- derivative was superior, displaying fast, selective tumor uptake and strong antitumor activity manifested by prolonged elimination of the treated tumors.

Název v anglickém jazyce

Novel porphyrin conjugates with a potent photodynamic antitumor effect: differential efficacy of mono- and bis-beta-cyclodextrin derivatives in vitro and in vivo

Popis výsledku anglicky

Photodynamic therapy employs systemic administration of a tumor-localizing photosensitizer followed by local irradiation of the tumor with visible light. The interaction between the excited photosensitizer and endogenous molecular oxygen generates reactive oxygen species, resulting in a cascade of biochemical events leading to cancer cell death. In the present study we investigated photosensitizing properties of two novel mono- and bis-cyclodextrin tetrakis (pentafluorophenyl) porphyrin derivatives in several tumor cell lines and in BALB/c mice bearing transplanted mammary carcinoma. Although both studied porphyrins exhibited similar intracellular localization, the mono-cyclodextrin derivative produced a stronger in vitro phototoxic effect than the bis-cyclodextrin derivative. In vivo, however, the efficacy of the bis- derivative was superior, displaying fast, selective tumor uptake and strong antitumor activity manifested by prolonged elimination of the treated tumors.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

EB - Genetika a molekulární biologie

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2006

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Photochemistry and Photobiology

ISSN

0031-8655

e-ISSN

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Svazek periodika

82

Číslo periodika v rámci svazku

2

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

7

Strana od-do

432-438

Kód UT WoS článku

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EID výsledku v databázi Scopus

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