Matrix metalloproteinase-19 is highly expressed in astroglial tumors and promotes invasion of glioma cells

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F10%3A00346779" target="_blank" >RIV/68378050:_____/10:00346779 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Matrix metalloproteinase-19 is highly expressed in astroglial tumors and promotes invasion of glioma cells

Popis výsledku v původním jazyce

Glial tumors exhibit a high morbidity and mortality because of their invasive nature. Matrix metalloproteinase 19 (MMP19) is a secreted protease that together with epilysin (MMP28) forms a structural subgroup of MMPs. In contrast, MMP19 was detected in normal brain samples only in endothelial cells but was found at high levels in astrocytomas. MMP19 was upregulated in GB cells after exposure to proinflammatory cytokines. MMP19-silenced cells migrated more slowly through laminin-, basal lamina-, and brevican-coated membranes than controls. MMP19-silenced GB cells also migrated into brain tissue slices compared with control cells. Brevican, a brain-specific proteoglycan and major component of brain extracellular matrix, was degraded by recombinant humanMMP19. MMP19 is highly expressed in proliferating astrocytoma/glioma cells and its expression may facilitate their invasion through brain extracellular matrix

Název v anglickém jazyce

Matrix metalloproteinase-19 is highly expressed in astroglial tumors and promotes invasion of glioma cells

Popis výsledku anglicky

Glial tumors exhibit a high morbidity and mortality because of their invasive nature. Matrix metalloproteinase 19 (MMP19) is a secreted protease that together with epilysin (MMP28) forms a structural subgroup of MMPs. In contrast, MMP19 was detected in normal brain samples only in endothelial cells but was found at high levels in astrocytomas. MMP19 was upregulated in GB cells after exposure to proinflammatory cytokines. MMP19-silenced cells migrated more slowly through laminin-, basal lamina-, and brevican-coated membranes than controls. MMP19-silenced GB cells also migrated into brain tissue slices compared with control cells. Brevican, a brain-specific proteoglycan and major component of brain extracellular matrix, was degraded by recombinant humanMMP19. MMP19 is highly expressed in proliferating astrocytoma/glioma cells and its expression may facilitate their invasion through brain extracellular matrix

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

EB - Genetika a molekulární biologie

OECD FORD obor

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Projekt

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Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2010

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Neuropathology and Experimental Neurology

ISSN

0022-3069

e-ISSN

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Svazek periodika

69

Číslo periodika v rámci svazku

3

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

9

Strana od-do

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Kód UT WoS článku

000275418600001

EID výsledku v databázi Scopus

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