Association of CD99 short and long forms with MHC class I, MHC class II and tetraspanin CD81 and recruitment into immunological synapses

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F11%3A00370115" target="_blank" >RIV/68378050:_____/11:00370115 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1186/1756-0500-4-293" target="_blank" >http://dx.doi.org/10.1186/1756-0500-4-293</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1186/1756-0500-4-293" target="_blank" >10.1186/1756-0500-4-293</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Association of CD99 short and long forms with MHC class I, MHC class II and tetraspanin CD81 and recruitment into immunological synapses

Popis výsledku v původním jazyce

We analyzed the association of CD99 with other cell surface molecules involved in T cell activation. We demonstrate the association of MHC class I, MHC class II and tetraspanin CD81 with CD99 molecules on the cell surface. Association of CD99 with its partners was observed for both isoforms. In addition, we determined that CD99 is a lipid raft-associated membrane protein and is recruited into the immunologic synapse during T cell activation. The implication of CD99 on T cell activation was investigated.Inhibition of anti-CD3 induced T cell proliferation by an anti-CD99 monoclonal antibody was observed.

Název v anglickém jazyce

Association of CD99 short and long forms with MHC class I, MHC class II and tetraspanin CD81 and recruitment into immunological synapses

Popis výsledku anglicky

We analyzed the association of CD99 with other cell surface molecules involved in T cell activation. We demonstrate the association of MHC class I, MHC class II and tetraspanin CD81 with CD99 molecules on the cell surface. Association of CD99 with its partners was observed for both isoforms. In addition, we determined that CD99 is a lipid raft-associated membrane protein and is recruited into the immunologic synapse during T cell activation. The implication of CD99 on T cell activation was investigated.Inhibition of anti-CD3 induced T cell proliferation by an anti-CD99 monoclonal antibody was observed.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

EB - Genetika a molekulární biologie

OECD FORD obor

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Projekt

—

Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2011

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

BMC Research Notes

ISSN

1756-0500

e-ISSN

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Svazek periodika

4

Číslo periodika v rámci svazku

—

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

13

Strana od-do

293

Kód UT WoS článku

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EID výsledku v databázi Scopus

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