Chicken models of retroviral insertional mutagenesis

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F11%3A00378894" target="_blank" >RIV/68378050:_____/11:00378894 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1007/978-1-4419-7656-7" target="_blank" >http://dx.doi.org/10.1007/978-1-4419-7656-7</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/978-1-4419-7656-7" target="_blank" >10.1007/978-1-4419-7656-7</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Chicken models of retroviral insertional mutagenesis

Popis výsledku v původním jazyce

The introductory part summarizes published results of searching for cancer-related genes obtained using chicken models of insertional mutagenesis and presents new views of mechanisms by which integrated proviruses deregulate host gene expression. The major part of the chapter is devoted to the most advanced model based on MAV-2 retrovirus that has been elaborated recently by the authors. So far the model allowed identification of genes participating in the formation of nephroblastomas, lung and liver hemangiosarcomas, liver carcinomas and cholangiocarcinomas. Most of these tumor types were induced with the help of the new phenomenon discovered recently by the authors: non-tumor cells released into the blood circulation and passing further into tissuesstrongly promote the formation of a tumor from latent malignant cells primed by MAV-2 insertional mutagenesis. The data described in the chapter are up-to-date and include the newest results of the authors that has not been published yet.

Název v anglickém jazyce

Chicken models of retroviral insertional mutagenesis

Popis výsledku anglicky

The introductory part summarizes published results of searching for cancer-related genes obtained using chicken models of insertional mutagenesis and presents new views of mechanisms by which integrated proviruses deregulate host gene expression. The major part of the chapter is devoted to the most advanced model based on MAV-2 retrovirus that has been elaborated recently by the authors. So far the model allowed identification of genes participating in the formation of nephroblastomas, lung and liver hemangiosarcomas, liver carcinomas and cholangiocarcinomas. Most of these tumor types were induced with the help of the new phenomenon discovered recently by the authors: non-tumor cells released into the blood circulation and passing further into tissuesstrongly promote the formation of a tumor from latent malignant cells primed by MAV-2 insertional mutagenesis. The data described in the chapter are up-to-date and include the newest results of the authors that has not been published yet.

Druh

C - Kapitola v odborné knize

CEP obor

EB - Genetika a molekulární biologie

OECD FORD obor

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Projekt

<a href="/cs/project/GA301%2F09%2F1727" target="_blank" >GA301/09/1727: Identifikace velkého počtu genů zodpovědných za tvorbu solidních nádorů</a><br>

Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2011

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název knihy nebo sborníku

Insertional Mutagenesis Strategies in Cancer Genetics

ISBN

978-1-4419-7655-0

Počet stran výsledku

36

Strana od-do

77-112

Počet stran knihy

200

Název nakladatele

Springer

Místo vydání

New York

Kód UT WoS kapitoly

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