Proviral integrations of MAV-2 retrovirus in the chicken genome

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F12%3A00377759" target="_blank" >RIV/68378050:_____/12:00377759 - isvavai.cz</a>

Výsledek na webu

<a href="http://mav-cis.img.cas.cz/results.html" target="_blank" >http://mav-cis.img.cas.cz/results.html</a>

DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Proviral integrations of MAV-2 retrovirus in the chicken genome

Popis výsledku v původním jazyce

The table of proviral insertion sites of MAV-2 retrovirus in the chicken genome. Myeloblastosis-associated virus 2 (MAV-2) is a chicken oncogenic retrovirus with the unique ability to induce development of various types of experimental tumors including nephroblastoma, angiosarcoma of lungs, liver and heart, liver carcinoma, cholangiocarcinoma and other rare tumor types. Genes found to be recurrently hit by clonal insertion of the MAV-2 provirus in independent clonal tumors are thought to be cancer genesand their deregulation/mutation is responsible for transformation of the host cell. We used a chicken MAV-2-based model of insertional mutagenesis to identify more than hundred of candidate genes whose deregulation could be responsible for the formationof chicken nephroblastoma, lung angiosarcoma, liver angiosarcoma, hepatocarcinoma and cholangiocarcinoma and for transformation in vitro. Detailed study of the cooperation of MAV-2 insertional mutagenesis and promotional effects of stray

Název v anglickém jazyce

Proviral integrations of MAV-2 retrovirus in the chicken genome

Popis výsledku anglicky

The table of proviral insertion sites of MAV-2 retrovirus in the chicken genome. Myeloblastosis-associated virus 2 (MAV-2) is a chicken oncogenic retrovirus with the unique ability to induce development of various types of experimental tumors including nephroblastoma, angiosarcoma of lungs, liver and heart, liver carcinoma, cholangiocarcinoma and other rare tumor types. Genes found to be recurrently hit by clonal insertion of the MAV-2 provirus in independent clonal tumors are thought to be cancer genesand their deregulation/mutation is responsible for transformation of the host cell. We used a chicken MAV-2-based model of insertional mutagenesis to identify more than hundred of candidate genes whose deregulation could be responsible for the formationof chicken nephroblastoma, lung angiosarcoma, liver angiosarcoma, hepatocarcinoma and cholangiocarcinoma and for transformation in vitro. Detailed study of the cooperation of MAV-2 insertional mutagenesis and promotional effects of stray

Druh

A - Audiovizuální tvorba

CEP obor

EB - Genetika a molekulární biologie

OECD FORD obor

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Projekt

<a href="/cs/project/GA301%2F09%2F1727" target="_blank" >GA301/09/1727: Identifikace velkého počtu genů zodpovědných za tvorbu solidních nádorů</a><br>

Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2012

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

ISBN

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Místo vydání

Praha

Název nakladatele resp. objednatele

Czech Science Foundation

Verze

1.

Identifikační číslo nosiče

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