Exploring avian cancer genome with insertional mutagenesis screens using myeloblastosis associated viruses

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F19%3A00523240" target="_blank" >RIV/68378050:_____/19:00523240 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Exploring avian cancer genome with insertional mutagenesis screens using myeloblastosis associated viruses

Popis výsledku v původním jazyce

We have established a new model for studying cancer genetics based on insertional mutagenesis by chicken retrovirus myeloblastosis-associated virus-2 (MAV-2) and tumor-promoting agents that target tumorigenesis into individual organs. Using high-performance iPCR we analyzed a large number of chicken tumors, pinpointed common provirus-insertion sites and associated them with candidate cancer genes. So far, we have defined the principal oncogenes driving formation of chicken nephroblastomas (FOXP1, PLAG1, TWIST or HRAS), lung hemangiosarcomas (FRK), liver hemangiosarcomas (HRAS), hepatocarcinomas (EGFR), and cholangiocarcinomas (HGFR or MST1R)(1-4). All of them are now proven human oncogenes, in three cases (TWIST, FOXP1, FRK), our findings preceded the discovery of their involvement in human tumors. This shows that non-mouse species are good alternative models for studying oncogenesis with outcomes applicable to human medicine.n

Název v anglickém jazyce

Exploring avian cancer genome with insertional mutagenesis screens using myeloblastosis associated viruses

Popis výsledku anglicky

We have established a new model for studying cancer genetics based on insertional mutagenesis by chicken retrovirus myeloblastosis-associated virus-2 (MAV-2) and tumor-promoting agents that target tumorigenesis into individual organs. Using high-performance iPCR we analyzed a large number of chicken tumors, pinpointed common provirus-insertion sites and associated them with candidate cancer genes. So far, we have defined the principal oncogenes driving formation of chicken nephroblastomas (FOXP1, PLAG1, TWIST or HRAS), lung hemangiosarcomas (FRK), liver hemangiosarcomas (HRAS), hepatocarcinomas (EGFR), and cholangiocarcinomas (HGFR or MST1R)(1-4). All of them are now proven human oncogenes, in three cases (TWIST, FOXP1, FRK), our findings preceded the discovery of their involvement in human tumors. This shows that non-mouse species are good alternative models for studying oncogenesis with outcomes applicable to human medicine.n

Druh

C - Kapitola v odborné knize

CEP obor

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OECD FORD obor

10607 - Virology

Projekt

<a href="/cs/project/LO1419" target="_blank" >LO1419: Biomodely pro zdraví - Centrum modelových organismů</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2019

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název knihy nebo sborníku

Advances in Disease Models

ISBN

978-80-88011-06-4

Počet stran výsledku

18

Strana od-do

189-206

Počet stran knihy

310

Název nakladatele

OPTIO CZ

Místo vydání

Praha

Kód UT WoS kapitoly

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