Phenotyping of circulating CD8(+) T cell subsets in human cutaneous leishmaniasis

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F12%3A00389981" target="_blank" >RIV/68378050:_____/12:00389981 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1016/j.micinf.2012.02.006" target="_blank" >http://dx.doi.org/10.1016/j.micinf.2012.02.006</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.micinf.2012.02.006" target="_blank" >10.1016/j.micinf.2012.02.006</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Phenotyping of circulating CD8(+) T cell subsets in human cutaneous leishmaniasis

Popis výsledku v původním jazyce

Recovery from CL is usually accompanied with long-lasting protection and induction of strong immune response. The phenotypes, generation and maintenance of central (=T-CM) and effector (=T-EM) memory T cell subsets in human leishmaniasis are not well known. Profile of T cell subsets were analyzed on peripheral CD8(+) T cells from volunteers with history of cutaneous leishmaniasis (HCL). In HCL and control groups, mean frequencies of CCR7(+)CD45RA(+)CD8(+) naive and CCR7(-)CD45RA(-)CD8(+) T-EM cells werehigher than other subsets before culture, but after stimulation with soluble Leishmania antigen, the frequency of naive T cells was significantly decreased and the frequency of T-EM cells was significantly increased. T-EM phenotype composed the highestportion of proliferating Carboxy Fluorescein diacetate Succinimidyl Ester (CFSE)-dim population which was significantly higher in HCL volunteers than in control group. Stimulation of isolated CD8(+) memory T cells, but not naive T cells,

Název v anglickém jazyce

Phenotyping of circulating CD8(+) T cell subsets in human cutaneous leishmaniasis

Popis výsledku anglicky

Recovery from CL is usually accompanied with long-lasting protection and induction of strong immune response. The phenotypes, generation and maintenance of central (=T-CM) and effector (=T-EM) memory T cell subsets in human leishmaniasis are not well known. Profile of T cell subsets were analyzed on peripheral CD8(+) T cells from volunteers with history of cutaneous leishmaniasis (HCL). In HCL and control groups, mean frequencies of CCR7(+)CD45RA(+)CD8(+) naive and CCR7(-)CD45RA(-)CD8(+) T-EM cells werehigher than other subsets before culture, but after stimulation with soluble Leishmania antigen, the frequency of naive T cells was significantly decreased and the frequency of T-EM cells was significantly increased. T-EM phenotype composed the highestportion of proliferating Carboxy Fluorescein diacetate Succinimidyl Ester (CFSE)-dim population which was significantly higher in HCL volunteers than in control group. Stimulation of isolated CD8(+) memory T cells, but not naive T cells,

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

EB - Genetika a molekulární biologie

OECD FORD obor

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Projekt

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Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2012

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Microbes and Infection

ISSN

1286-4579

e-ISSN

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Svazek periodika

14

Číslo periodika v rámci svazku

9

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

10

Strana od-do

702-711

Kód UT WoS článku

000306877700005

EID výsledku v databázi Scopus

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