CD8(+) Tregs revisited: A heterogeneous population with different phenotypes and properties

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F21%3A00544971" target="_blank" >RIV/68378050:_____/21:00544971 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11310/21:10438694

Výsledek na webu

<a href="https://onlinelibrary.wiley.com/doi/10.1002/eji.202048614" target="_blank" >https://onlinelibrary.wiley.com/doi/10.1002/eji.202048614</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1002/eji.202048614" target="_blank" >10.1002/eji.202048614</a>

Jazyk výsledku

angličtina

Název v původním jazyce

CD8(+) Tregs revisited: A heterogeneous population with different phenotypes and properties

Popis výsledku v původním jazyce

Regulatory T cells (Tregs) play a key role in the peripheral self-tolerance and preventing autoimmunity. While classical CD4(+) Foxp3(+) Tregs are well established, their CD8(+) counterparts are still controversial in many aspects including their phenotypic identity and their mechanisms of suppression. Because of these controversies and because of only a limited number of studies documenting the immunoregulatory function of CD8(+) Tregs in vivo, the concept of CD8(+) Tregs is still not unanimously accepted. We propose that any T-cell subset considered as true regulatory must be distinguishable from other cell types and must suppress in vivo immune responses via a known mechanism. In this article, we revisit the concept of CD8(+) Tregs by focusing on the characterization of individual CD8(+) T-cell subsets with proposed regulatory capacity separately. Therefore, we review the phenotype and function of CD8(+) FOXP3(+) T cells, CD8(+) CD122(+) T cells, CD8(+) CD28(low/-) T cells, CD8(+) CD45RC(low) T cells, T cells expressing CD8 alpha alpha homodimer and Qa-1-restricted CD8(+) T cells to show whether there is sufficient evidence to establish these subsets as bona fide Tregs. Based on the intrinsic ability of CD8(+) Treg subsets to promote immune tolerance in animal models, we elaborate on their potential use in clinics.

Název v anglickém jazyce

CD8(+) Tregs revisited: A heterogeneous population with different phenotypes and properties

Popis výsledku anglicky

Regulatory T cells (Tregs) play a key role in the peripheral self-tolerance and preventing autoimmunity. While classical CD4(+) Foxp3(+) Tregs are well established, their CD8(+) counterparts are still controversial in many aspects including their phenotypic identity and their mechanisms of suppression. Because of these controversies and because of only a limited number of studies documenting the immunoregulatory function of CD8(+) Tregs in vivo, the concept of CD8(+) Tregs is still not unanimously accepted. We propose that any T-cell subset considered as true regulatory must be distinguishable from other cell types and must suppress in vivo immune responses via a known mechanism. In this article, we revisit the concept of CD8(+) Tregs by focusing on the characterization of individual CD8(+) T-cell subsets with proposed regulatory capacity separately. Therefore, we review the phenotype and function of CD8(+) FOXP3(+) T cells, CD8(+) CD122(+) T cells, CD8(+) CD28(low/-) T cells, CD8(+) CD45RC(low) T cells, T cells expressing CD8 alpha alpha homodimer and Qa-1-restricted CD8(+) T cells to show whether there is sufficient evidence to establish these subsets as bona fide Tregs. Based on the intrinsic ability of CD8(+) Treg subsets to promote immune tolerance in animal models, we elaborate on their potential use in clinics.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30102 - Immunology

Projekt

<a href="/cs/project/GJ19-03435Y" target="_blank" >GJ19-03435Y: Naivní, paměťové a virtuální paměťové buňky v adaptivních imunitních odpovědích</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2021

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

European Journal of Immunology

ISSN

0014-2980

e-ISSN

1521-4141

Svazek periodika

51

Číslo periodika v rámci svazku

3

Stát vydavatele periodika

DE - Spolková republika Německo

Počet stran výsledku

19

Strana od-do

512-530

Kód UT WoS článku

000619568300001

EID výsledku v databázi Scopus

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