Investigation of the complex structure, comparative DNA-binding and DNA cleavage of two water-soluble mono-nuclear lanthanum(III) complexes and cytotoxic activity of chitosan-coated magnetic nanoparticles as drug delivery for the complexes
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378271%3A_____%2F17%3A00479320" target="_blank" >RIV/68378271:_____/17:00479320 - isvavai.cz</a>
Výsledek na webu
<a href="http://dx.doi.org/10.1016/j.saa.2017.01.037" target="_blank" >http://dx.doi.org/10.1016/j.saa.2017.01.037</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.saa.2017.01.037" target="_blank" >10.1016/j.saa.2017.01.037</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Investigation of the complex structure, comparative DNA-binding and DNA cleavage of two water-soluble mono-nuclear lanthanum(III) complexes and cytotoxic activity of chitosan-coated magnetic nanoparticles as drug delivery for the complexes
Popis výsledku v původním jazyce
Two water-soluble mono-nuclear macrocyclic lanthanum(III) complexes of 2,6-diformyl-4-methylphenol with 1,3-diamino-2-propanol (C1) or 1,3-propylenediamine (C2) were synthesized and characterized by various analysis. The interaction of complexes with DNA was studied in buffered aqueous solution at pH 7.4. UV–Vis absorption spectroscopy, emission spectroscopy, circular dichroism (CD) and viscometric measurements provided evidence of the intercalation mechanism of binding. The obtained intrinsic binding constants (Kb) 9.3×103 and 1.2 × 103 M-1 for C1 and C2, respectively confirmed that C1 is better intercalator than C2. The anticancer experiments for the treated cancerous cell lines with both compounds show that these hydrophilic molecules need a suitable carrier to pass through the hydrophobic nature of cell membrane efficiently.
Název v anglickém jazyce
Investigation of the complex structure, comparative DNA-binding and DNA cleavage of two water-soluble mono-nuclear lanthanum(III) complexes and cytotoxic activity of chitosan-coated magnetic nanoparticles as drug delivery for the complexes
Popis výsledku anglicky
Two water-soluble mono-nuclear macrocyclic lanthanum(III) complexes of 2,6-diformyl-4-methylphenol with 1,3-diamino-2-propanol (C1) or 1,3-propylenediamine (C2) were synthesized and characterized by various analysis. The interaction of complexes with DNA was studied in buffered aqueous solution at pH 7.4. UV–Vis absorption spectroscopy, emission spectroscopy, circular dichroism (CD) and viscometric measurements provided evidence of the intercalation mechanism of binding. The obtained intrinsic binding constants (Kb) 9.3×103 and 1.2 × 103 M-1 for C1 and C2, respectively confirmed that C1 is better intercalator than C2. The anticancer experiments for the treated cancerous cell lines with both compounds show that these hydrophilic molecules need a suitable carrier to pass through the hydrophobic nature of cell membrane efficiently.
Klasifikace
Druh
J<sub>imp</sub> - Článek v periodiku v databázi Web of Science
CEP obor
—
OECD FORD obor
10302 - Condensed matter physics (including formerly solid state physics, supercond.)
Návaznosti výsledku
Projekt
Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.
Návaznosti
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Ostatní
Rok uplatnění
2017
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy
ISSN
1386-1425
e-ISSN
—
Svazek periodika
178
Číslo periodika v rámci svazku
May
Stát vydavatele periodika
NL - Nizozemsko
Počet stran výsledku
11
Strana od-do
125-135
Kód UT WoS článku
000397370000017
EID výsledku v databázi Scopus
2-s2.0-85011392064