Homodinuclear Ni (II) and Cu (II) Schiff base complexes derived from O-vanillin with a pyrazole bridge: preparation, crystal structures, DNA and protein (BSA) binding, DNA cleavage, molecular docking and cytotoxicity study
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378271%3A_____%2F19%3A00505129" target="_blank" >RIV/68378271:_____/19:00505129 - isvavai.cz</a>
Výsledek na webu
<a href="https://doi.org/10.1016/j.jphotochem.2019.02.001" target="_blank" >https://doi.org/10.1016/j.jphotochem.2019.02.001</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.jphotochem.2019.02.001" target="_blank" >10.1016/j.jphotochem.2019.02.001</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Homodinuclear Ni (II) and Cu (II) Schiff base complexes derived from O-vanillin with a pyrazole bridge: preparation, crystal structures, DNA and protein (BSA) binding, DNA cleavage, molecular docking and cytotoxicity study
Popis výsledku v původním jazyce
Two homodinuclear complexes [Ni2(L)(μ-pz)] (C1) and [Cu2(L)(μ-pz)] (C2) (L=N,N′-bis(3-methoxysalicylidene)-1,3-diamino-2-propanol) were synthesized and characterized by elemental analysis, spectroscopic methods and single crystal X-ray crystallography. The crystal structure of both complexes revealed that two metal atoms were doubly bridged by one alkoxo group as an endogenous bridge and one pyrazolate as exogenous bridge. The arrangement around each metal atom was square planar. Interaction of C1 & C2 with HS-DNA and protein was investigated by UV–vis and fluorescence spectroscopy. Viscosity measurements, cyclic voltammetry, circular dichroism and agarose gel electrophoresis were used in the interaction with DNA. These complexes were also investigated in the interaction with BSA.
Název v anglickém jazyce
Homodinuclear Ni (II) and Cu (II) Schiff base complexes derived from O-vanillin with a pyrazole bridge: preparation, crystal structures, DNA and protein (BSA) binding, DNA cleavage, molecular docking and cytotoxicity study
Popis výsledku anglicky
Two homodinuclear complexes [Ni2(L)(μ-pz)] (C1) and [Cu2(L)(μ-pz)] (C2) (L=N,N′-bis(3-methoxysalicylidene)-1,3-diamino-2-propanol) were synthesized and characterized by elemental analysis, spectroscopic methods and single crystal X-ray crystallography. The crystal structure of both complexes revealed that two metal atoms were doubly bridged by one alkoxo group as an endogenous bridge and one pyrazolate as exogenous bridge. The arrangement around each metal atom was square planar. Interaction of C1 & C2 with HS-DNA and protein was investigated by UV–vis and fluorescence spectroscopy. Viscosity measurements, cyclic voltammetry, circular dichroism and agarose gel electrophoresis were used in the interaction with DNA. These complexes were also investigated in the interaction with BSA.
Klasifikace
Druh
J<sub>imp</sub> - Článek v periodiku v databázi Web of Science
CEP obor
—
OECD FORD obor
10302 - Condensed matter physics (including formerly solid state physics, supercond.)
Návaznosti výsledku
Projekt
Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.
Návaznosti
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Ostatní
Rok uplatnění
2019
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
Journal of Photochemistry and Photobiology A-Chemistry
ISSN
1010-6030
e-ISSN
—
Svazek periodika
374
Číslo periodika v rámci svazku
Apr
Stát vydavatele periodika
CH - Švýcarská konfederace
Počet stran výsledku
16
Strana od-do
145-160
Kód UT WoS článku
000460717900018
EID výsledku v databázi Scopus
2-s2.0-85061151379