Targeting the mTOR signaling pathway utilizing nanoparticles: A critical overview

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378271%3A_____%2F19%3A00521400" target="_blank" >RIV/68378271:_____/19:00521400 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/68378041:_____/19:00508393 RIV/00023001:_____/19:00077655

Výsledek na webu

<a href="http://hdl.handle.net/11104/0306033" target="_blank" >http://hdl.handle.net/11104/0306033</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3390/cancers11010082" target="_blank" >10.3390/cancers11010082</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Targeting the mTOR signaling pathway utilizing nanoparticles: A critical overview

Popis výsledku v původním jazyce

Proteins of the mammalian target of rapamycin (mTOR) signaling axis are overexpressed or mutated in cancers. However, clinical inhibition of mTOR signaling as a therapeutic strategy in oncology shows rather limited progress. Nanoparticle-based mTOR targeted therapy proposes an attractive therapeutic option for various types of cancers. Here, we critically analyze the current literature on the modulation of mTOR activity by nanoparticles, demonstrate the complexity of cellular responses to functionalized nanoparticles, and underline challenges lying in the identification of the molecular mechanisms of mTOR signaling affected by nanoparticles. We propose the idea that subcytotoxic doses of nanoparticles could be relevant for the induction of subcellular structural changes with possible involvement of mTORC1 signaling. The evaluation of the mechanisms of nanoparticle-based mTOR modulation will provide fundamental knowledge which could help in developing efficient nano-therapeutics.n

Název v anglickém jazyce

Targeting the mTOR signaling pathway utilizing nanoparticles: A critical overview

Popis výsledku anglicky

Proteins of the mammalian target of rapamycin (mTOR) signaling axis are overexpressed or mutated in cancers. However, clinical inhibition of mTOR signaling as a therapeutic strategy in oncology shows rather limited progress. Nanoparticle-based mTOR targeted therapy proposes an attractive therapeutic option for various types of cancers. Here, we critically analyze the current literature on the modulation of mTOR activity by nanoparticles, demonstrate the complexity of cellular responses to functionalized nanoparticles, and underline challenges lying in the identification of the molecular mechanisms of mTOR signaling affected by nanoparticles. We propose the idea that subcytotoxic doses of nanoparticles could be relevant for the induction of subcellular structural changes with possible involvement of mTORC1 signaling. The evaluation of the mechanisms of nanoparticle-based mTOR modulation will provide fundamental knowledge which could help in developing efficient nano-therapeutics.n

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10610 - Biophysics

Projekt

<a href="/cs/project/EF16_019%2F0000760" target="_blank" >EF16_019/0000760: Fyzika pevných látek pro 21. století</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2019

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Cancers (Basel)

ISSN

2072-6694

e-ISSN

—

Svazek periodika

11

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

CH - Švýcarská konfederace

Počet stran výsledku

18

Strana od-do

1-18

Kód UT WoS článku

000457233300002

EID výsledku v databázi Scopus

2-s2.0-85061974155