The ε-AlxFe2-xO3 nanomagnets as MRI contrast agents: Factors influencing transverse relaxivity

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378271%3A_____%2F20%3A00532457" target="_blank" >RIV/68378271:_____/20:00532457 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/60461373:22340/20:43919634

Výsledek na webu

<a href="https://doi.org/10.1016/j.colsurfa.2020.124423" target="_blank" >https://doi.org/10.1016/j.colsurfa.2020.124423</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.colsurfa.2020.124423" target="_blank" >10.1016/j.colsurfa.2020.124423</a>

Jazyk výsledku

angličtina

Název v původním jazyce

The ε-AlxFe2-xO3 nanomagnets as MRI contrast agents: Factors influencing transverse relaxivity

Popis výsledku v původním jazyce

Novel type of contrast agents based on non-superparamagnetic nanoparticles of aluminum-doped epsilon polymorph of Fe2O3 is suggested and used as a model system to elucidate the role of magnetic blocking and other factors in the transverse relaxation of water. Specifically, the dependence of the transverse relaxivity r2 on the magnetic field, temperature, magnetization, surface modification and thickness of silica coating is analyzed for the epsilon-AlxFe2-xO3 nanoparticles with x = 0.23 and the median size of 21 nm. Irreversible magnetization processes in aqueous suspension of coated clusters of magnetic crystallites resulted in the field dependence of r2. The temperature dependence of r2 was interpreted by the combination of two different regimes - motional averaging and static dephasing regimes. Moreover, the performance of the contrast agent was demonstrated not only in ultra-high-field MRI at 11.75 T but also by imaging in vivo on a mouse model at 1 T.

Název v anglickém jazyce

The ε-AlxFe2-xO3 nanomagnets as MRI contrast agents: Factors influencing transverse relaxivity

Popis výsledku anglicky

Novel type of contrast agents based on non-superparamagnetic nanoparticles of aluminum-doped epsilon polymorph of Fe2O3 is suggested and used as a model system to elucidate the role of magnetic blocking and other factors in the transverse relaxation of water. Specifically, the dependence of the transverse relaxivity r2 on the magnetic field, temperature, magnetization, surface modification and thickness of silica coating is analyzed for the epsilon-AlxFe2-xO3 nanoparticles with x = 0.23 and the median size of 21 nm. Irreversible magnetization processes in aqueous suspension of coated clusters of magnetic crystallites resulted in the field dependence of r2. The temperature dependence of r2 was interpreted by the combination of two different regimes - motional averaging and static dephasing regimes. Moreover, the performance of the contrast agent was demonstrated not only in ultra-high-field MRI at 11.75 T but also by imaging in vivo on a mouse model at 1 T.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10302 - Condensed matter physics (including formerly solid state physics, supercond.)

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2020

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Colloids and Surfaces. A - Physicochemical and Engineering Aspects

ISSN

0927-7757

e-ISSN

—

Svazek periodika

589

Číslo periodika v rámci svazku

Feb

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

11

Strana od-do

1-11

Kód UT WoS článku

000513861400023

EID výsledku v databázi Scopus

2-s2.0-85077507452