Magnetron-sputtered niobium nanoparticles for molecular imaging of brain tissues through surface-assisted laser desorption/ionization mass spectrometry

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378271%3A_____%2F22%3A00564922" target="_blank" >RIV/68378271:_____/22:00564922 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11320/22:10451744 RIV/00216224:14310/22:00129244

Výsledek na webu

<a href="https://doi.org/10.1021/acsanm.2c02734" target="_blank" >https://doi.org/10.1021/acsanm.2c02734</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1021/acsanm.2c02734" target="_blank" >10.1021/acsanm.2c02734</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Magnetron-sputtered niobium nanoparticles for molecular imaging of brain tissues through surface-assisted laser desorption/ionization mass spectrometry

Popis výsledku v původním jazyce

The Nb NPs are synthesized by a magnetron sputtering inert gas aggregation technique, which avoids the use of wet chemical pathways and allows the direct deposition of the NPs onto biological specimens. The NPs are partially oxidized and consist of a body-centered cubic (bcc) polycrystalline metal Nb core enclosed by an amorphous Nb2O5 shell. When seeded onto slices of the mouse brain, the Nb NPs form an effective matrix for high-resolution SALDI MSI of complex biological samples in both negative and positive ionization modes. The use of ultrahigh-resolution mass spectrometry allowed the identification of different Nb adducts and multiple phospholipid ion classes at m/z < 1000 This work qualifies Nb NPs as an efficient, accessible, and easy-to-handle matrix for SALDI MSI for the first time. In addition, it highlights the potential utilization of other, yet unexplored transition-metal NPs, motivating their future research.

Název v anglickém jazyce

Magnetron-sputtered niobium nanoparticles for molecular imaging of brain tissues through surface-assisted laser desorption/ionization mass spectrometry

Popis výsledku anglicky

The Nb NPs are synthesized by a magnetron sputtering inert gas aggregation technique, which avoids the use of wet chemical pathways and allows the direct deposition of the NPs onto biological specimens. The NPs are partially oxidized and consist of a body-centered cubic (bcc) polycrystalline metal Nb core enclosed by an amorphous Nb2O5 shell. When seeded onto slices of the mouse brain, the Nb NPs form an effective matrix for high-resolution SALDI MSI of complex biological samples in both negative and positive ionization modes. The use of ultrahigh-resolution mass spectrometry allowed the identification of different Nb adducts and multiple phospholipid ion classes at m/z < 1000 This work qualifies Nb NPs as an efficient, accessible, and easy-to-handle matrix for SALDI MSI for the first time. In addition, it highlights the potential utilization of other, yet unexplored transition-metal NPs, motivating their future research.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

21002 - Nano-processes (applications on nano-scale); (biomaterials to be 2.9)

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2022

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

ACS Applied Nano Materials

ISSN

2574-0970

e-ISSN

—

Svazek periodika

5

Číslo periodika v rámci svazku

9

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

11

Strana od-do

12865-12875

Kód UT WoS článku

000859044000001

EID výsledku v databázi Scopus

2-s2.0-85138770225