Radial flow enhances QCM biosensor sensitivity

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378271%3A_____%2F24%3A00585171" target="_blank" >RIV/68378271:_____/24:00585171 - isvavai.cz</a>

Výsledek na webu

<a href="https://doi.org/10.1016/j.snb.2023.134949" target="_blank" >https://doi.org/10.1016/j.snb.2023.134949</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.snb.2023.134949" target="_blank" >10.1016/j.snb.2023.134949</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Radial flow enhances QCM biosensor sensitivity

Popis výsledku v původním jazyce

QCM biosensors are widely used for the detection of a variety of pathogenic microorganisms, and there remains a need for further increases in sensitivity. The majority of QCM biosensors are operated under diffusion-limited conditions that, when used with a standard flow cell, lead to the majority of analyte being captured onto re- gions of the crystal surface that have limited to no mass sensitivity. Here we show that simple changes to a flow cell architecture (reduction of flow cell height) can provide increases in sensing signal. Furthermore, we show that the use of radial flow will lead to analyte capture directly in the sensitive region of a crystal, thus providing dramatic increases in the biosensor’s sensitivity. We examine this problem from both a theoretical and numerical perspective and present a new method by which to consider how changes to a sensing assay will affect sensor sensitivity.

Název v anglickém jazyce

Radial flow enhances QCM biosensor sensitivity

Popis výsledku anglicky

QCM biosensors are widely used for the detection of a variety of pathogenic microorganisms, and there remains a need for further increases in sensitivity. The majority of QCM biosensors are operated under diffusion-limited conditions that, when used with a standard flow cell, lead to the majority of analyte being captured onto re- gions of the crystal surface that have limited to no mass sensitivity. Here we show that simple changes to a flow cell architecture (reduction of flow cell height) can provide increases in sensing signal. Furthermore, we show that the use of radial flow will lead to analyte capture directly in the sensitive region of a crystal, thus providing dramatic increases in the biosensor’s sensitivity. We examine this problem from both a theoretical and numerical perspective and present a new method by which to consider how changes to a sensing assay will affect sensor sensitivity.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10610 - Biophysics

Projekt

<a href="/cs/project/GA22-20012S" target="_blank" >GA22-20012S: Objasnění a odstranění nespecifické biomolekulární adsorpce pomocí polymerních kartáčů s kontrolovanou 3D nanostrukturou</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2024

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Sensors and Actuators B - Chemical

ISSN

0925-4005

e-ISSN

0925-4005

Svazek periodika

401

Číslo periodika v rámci svazku

Feb

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

8

Strana od-do

134949

Kód UT WoS článku

001146836700001

EID výsledku v databázi Scopus

2-s2.0-85177204100