High resolution X-ray micro-CT imaging of fibrin scaffold using large area single photon counting detector

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378297%3A_____%2F18%3A00497929" target="_blank" >RIV/68378297:_____/18:00497929 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/68407700:21670/18:00329977

Výsledek na webu

<a href="https://doi.org/10.1088/1748-0221/13/12/C12006" target="_blank" >https://doi.org/10.1088/1748-0221/13/12/C12006</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1088/1748-0221/13/12/C12006" target="_blank" >10.1088/1748-0221/13/12/C12006</a>

Jazyk výsledku

angličtina

Název v původním jazyce

High resolution X-ray micro-CT imaging of fibrin scaffold using large area single photon counting detector

Popis výsledku v původním jazyce

This paper deals with the high resolution X-ray micro-computed tomographical (micro-CT) visualization of a fibrin scaffold intended to be used during medical repairs of various types of human tissue. Due to the cellular nature of scaffolds, it is important to inspect their Microstructure in high detail on a volumetric basis. In this work, we demonstrate the micro-CT measurement of a fibrin-based bone scaffold performed using a proprietarily developed tomographical scanner equipped with a large-area imaging device (LAD) composed of 10 x 10 Timepix silicon pixel detectors without any gaps between the individual tiles. The fibrin scaffolds are based on organic materials, which may be reinforced by various additives to improve their mechanical characteristics, and their dimensions are generally very small (i.e. micrometer to millimeter scale). As the organic material used in fibrin scaffolds exhibits very low X-ray attenuation, low-energy X-ray radiation is desirable to achieve sufficient contrast in the projections. Moreover, a high resolution is needed to visualize the fine features in the scaffolds. Here, conventional scintillation detectors suffer two problems that make the aforementioned LAD superior for the imaging of the investigated scaffolds: a wide point-spread function and low sensitivity at low energies. Despite the high LAD sensitivity to low-energy photons, it was necessary to apply several correction procedures to achieve the highest possible resolution. Here, a computational procedure was developed to compensate for the drift of the tube’s focal spot, geometrical imperfections of the LAD detector assembly, and the effects of its border pixels with different responses and sizes. We demonstrate the results on the final reconstructed images based on uncorrected and corrected projections, where we achieved a 1 μm voxel size.

Název v anglickém jazyce

High resolution X-ray micro-CT imaging of fibrin scaffold using large area single photon counting detector

Popis výsledku anglicky

This paper deals with the high resolution X-ray micro-computed tomographical (micro-CT) visualization of a fibrin scaffold intended to be used during medical repairs of various types of human tissue. Due to the cellular nature of scaffolds, it is important to inspect their Microstructure in high detail on a volumetric basis. In this work, we demonstrate the micro-CT measurement of a fibrin-based bone scaffold performed using a proprietarily developed tomographical scanner equipped with a large-area imaging device (LAD) composed of 10 x 10 Timepix silicon pixel detectors without any gaps between the individual tiles. The fibrin scaffolds are based on organic materials, which may be reinforced by various additives to improve their mechanical characteristics, and their dimensions are generally very small (i.e. micrometer to millimeter scale). As the organic material used in fibrin scaffolds exhibits very low X-ray attenuation, low-energy X-ray radiation is desirable to achieve sufficient contrast in the projections. Moreover, a high resolution is needed to visualize the fine features in the scaffolds. Here, conventional scintillation detectors suffer two problems that make the aforementioned LAD superior for the imaging of the investigated scaffolds: a wide point-spread function and low sensitivity at low energies. Despite the high LAD sensitivity to low-energy photons, it was necessary to apply several correction procedures to achieve the highest possible resolution. Here, a computational procedure was developed to compensate for the drift of the tube’s focal spot, geometrical imperfections of the LAD detector assembly, and the effects of its border pixels with different responses and sizes. We demonstrate the results on the final reconstructed images based on uncorrected and corrected projections, where we achieved a 1 μm voxel size.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

20302 - Applied mechanics

Projekt

<a href="/cs/project/EF16_019%2F0000766" target="_blank" >EF16_019/0000766: Inženýrské aplikace fyziky mikrosvěta</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2018

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Instrumentation

ISSN

1748-0221

e-ISSN

—

Svazek periodika

13

Číslo periodika v rámci svazku

12

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

12

Strana od-do

—

Kód UT WoS článku

000452801600001

EID výsledku v databázi Scopus

2-s2.0-85059917084