Is speech function lateralised in the basal ganglia? Evidence from de novo Parkinson's disease

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68407700%3A21230%2F25%3A00383247" target="_blank" >RIV/68407700:21230/25:00383247 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11110/25:10486092 RIV/00064165:_____/25:10486092

Výsledek na webu

<a href="https://doi.org/10.1136/jnnp-2024-334297" target="_blank" >https://doi.org/10.1136/jnnp-2024-334297</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1136/jnnp-2024-334297" target="_blank" >10.1136/jnnp-2024-334297</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Is speech function lateralised in the basal ganglia? Evidence from de novo Parkinson's disease

Popis výsledku v původním jazyce

Background Research on the possible influence of lateralised basal ganglia dysfunction on speech in Parkinson's disease is scarce. This study aimed to compare speech in de-novo, drug-naive patients with Parkinson's disease (PD) with asymmetric nigral dopaminergic dysfunction, predominantly in either the right or left hemisphere. Methods Acoustic analyses of reading passages were performed. Asymmetry of nigral dysfunction was defined using dopamine transporter-single-photon emission CT (DAT-SPECT). Results From a total of 135 de novo patients with PD assessed, 47 patients had a lower right and 36 lower left DAT availability in putamen based on DAT-SPECT. Patients with PD with lower left DAT availability had higher dysarthria severity via composite dysarthria index compared with patients with lower right DAT availability (p=0.01). Conclusion Our data support the crucial role of DAT availability in the left putamen in speech. This finding might provide important clues for managing speech following deep brain stimulation.

Název v anglickém jazyce

Is speech function lateralised in the basal ganglia? Evidence from de novo Parkinson's disease

Popis výsledku anglicky

Background Research on the possible influence of lateralised basal ganglia dysfunction on speech in Parkinson's disease is scarce. This study aimed to compare speech in de-novo, drug-naive patients with Parkinson's disease (PD) with asymmetric nigral dopaminergic dysfunction, predominantly in either the right or left hemisphere. Methods Acoustic analyses of reading passages were performed. Asymmetry of nigral dysfunction was defined using dopamine transporter-single-photon emission CT (DAT-SPECT). Results From a total of 135 de novo patients with PD assessed, 47 patients had a lower right and 36 lower left DAT availability in putamen based on DAT-SPECT. Patients with PD with lower left DAT availability had higher dysarthria severity via composite dysarthria index compared with patients with lower right DAT availability (p=0.01). Conclusion Our data support the crucial role of DAT availability in the left putamen in speech. This finding might provide important clues for managing speech following deep brain stimulation.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30210 - Clinical neurology

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2025

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Neurology, Neurosurgery, and Psychiatry

ISSN

0022-3050

e-ISSN

1468-330X

Svazek periodika

96

Číslo periodika v rámci svazku

5

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

4

Strana od-do

462-465

Kód UT WoS článku

001320540800001

EID výsledku v databázi Scopus

2-s2.0-85204973743