Radiation sensitivity of biological systems, its modification by chemical modifiers and its quantitative evaluation

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68407700%3A21340%2F24%3A00377945" target="_blank" >RIV/68407700:21340/24:00377945 - isvavai.cz</a>

Výsledek na webu

<a href="https://doi.org/10.1007/s10967-024-09611-6" target="_blank" >https://doi.org/10.1007/s10967-024-09611-6</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s10967-024-09611-6" target="_blank" >10.1007/s10967-024-09611-6</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Radiation sensitivity of biological systems, its modification by chemical modifiers and its quantitative evaluation

Popis výsledku v původním jazyce

Large number of sensitizers and protectors of cells, tissues, organs and organisms are being discussed in this review. Attention is paid to metals, nanoparticles or organic compounds as modifiers. They can modify the radiation sensitivity by 20-60%. In most cases, sensitization is caused by an increase in DNA damage or a decrease in the repair of radiation damage. The protection can be caused in many cases by repair of damaged DNA molecules, proteins or enzymes, or by reducing the ROS concentration. The most current research tasks in this area are formulated. A new quantitative and reproducible method of evaluating modifiers is discussed.

Název v anglickém jazyce

Radiation sensitivity of biological systems, its modification by chemical modifiers and its quantitative evaluation

Popis výsledku anglicky

Large number of sensitizers and protectors of cells, tissues, organs and organisms are being discussed in this review. Attention is paid to metals, nanoparticles or organic compounds as modifiers. They can modify the radiation sensitivity by 20-60%. In most cases, sensitization is caused by an increase in DNA damage or a decrease in the repair of radiation damage. The protection can be caused in many cases by repair of damaged DNA molecules, proteins or enzymes, or by reducing the ROS concentration. The most current research tasks in this area are formulated. A new quantitative and reproducible method of evaluating modifiers is discussed.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10400 - Chemical sciences

Projekt

<a href="/cs/project/EF16_019%2F0000778" target="_blank" >EF16_019/0000778: Centrum pokročilých aplikovaných přírodních věd</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2024

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Radioanalytical and Nuclear Chemistry

ISSN

0236-5731

e-ISSN

1588-2780

Svazek periodika

333

Číslo periodika v rámci svazku

9

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

27

Strana od-do

4443-4469

Kód UT WoS článku

001261480000002

EID výsledku v databázi Scopus

2-s2.0-85197944270