Effects of Echinochrome on Ventricular Repolarization in Acute Ischemia

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68407700%3A21460%2F14%3A00218888" target="_blank" >RIV/68407700:21460/14:00218888 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Effects of Echinochrome on Ventricular Repolarization in Acute Ischemia

Popis výsledku v původním jazyce

Ischemia-related processes, including electrophysiological alterations, are associated with the generation of reactive oxygen species. Although the cardioprotective action of antioxidants against ischemic injury has been proposed, their electrophysiological effects are not clear. The aim of this study was to investigate the effects of the antioxidant Echinochrome on ischemia-induced alterations of ventricular repolarization in a feline model of coronary occlusion. Experiments were performed on open-chest anesthetized adult cats. Activation-recovery intervals were measured from 64 ventricular epicardial unipolar electrograms recorded simultaneously before and during ligation of the left anterior descending coronary artery. Synthetic Echinochrome was infused five minutes before coronary occlusion in two different doses (1.0 mg/kg and 2.0 mg/kg, i.v.). Pre-occlusion administration of Echinochrome in a dose of 1.0 mg/kg resulted in the reduction of ischemiainduced shortening of activation-

Název v anglickém jazyce

Effects of Echinochrome on Ventricular Repolarization in Acute Ischemia

Popis výsledku anglicky

Ischemia-related processes, including electrophysiological alterations, are associated with the generation of reactive oxygen species. Although the cardioprotective action of antioxidants against ischemic injury has been proposed, their electrophysiological effects are not clear. The aim of this study was to investigate the effects of the antioxidant Echinochrome on ischemia-induced alterations of ventricular repolarization in a feline model of coronary occlusion. Experiments were performed on open-chest anesthetized adult cats. Activation-recovery intervals were measured from 64 ventricular epicardial unipolar electrograms recorded simultaneously before and during ligation of the left anterior descending coronary artery. Synthetic Echinochrome was infused five minutes before coronary occlusion in two different doses (1.0 mg/kg and 2.0 mg/kg, i.v.). Pre-occlusion administration of Echinochrome in a dose of 1.0 mg/kg resulted in the reduction of ischemiainduced shortening of activation-

Druh

D - Stať ve sborníku

CEP obor

ED - Fyziologie

OECD FORD obor

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Projekt

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Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2014

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název statě ve sborníku

Electrocardiology 2014 Proceedings

ISBN

978-80-969672-7-8

ISSN

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e-ISSN

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Počet stran výsledku

4

Strana od-do

121-124

Název nakladatele

Institute of Measurement Science

Místo vydání

Bratislava

Místo konání akce

Bratislava

Datum konání akce

4. 6. 2014

Typ akce podle státní příslušnosti

WRD - Celosvětová akce

Kód UT WoS článku

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