Effects of Echinochrome on Ventricular Repolarization in Acute Ischemia

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68407700%3A21460%2F15%3A00239026" target="_blank" >RIV/68407700:21460/15:00239026 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1016/j.jelectrocard.2015.01.003" target="_blank" >http://dx.doi.org/10.1016/j.jelectrocard.2015.01.003</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.jelectrocard.2015.01.003" target="_blank" >10.1016/j.jelectrocard.2015.01.003</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Effects of Echinochrome on Ventricular Repolarization in Acute Ischemia

Popis výsledku v původním jazyce

Background: Myocardial ischemic electrophysiological alterations are associated with the generation of reactive oxygen species. However, electrophysiological effects of antioxidants are unclear. Our objective was to determine the effects of the antioxidant echinochrome on ventricular repolarization in a feline model of 30-min ischemia. Methods and results: Activation recovery intervals were measured from 64 ventricular electrograms recorded before and during the LAD ligation in untreated animals (controls, n = 5) and animals given echinochrome (1 mg/kg, n = 5 and 2 mg/kg, n = 7). In controls, ischemia resulted in the increase of repolarization dispersion, QTc and Tpeak Tend intervals and precordial T wave amplitude dispersion. Echinochrome attenuated the ischemic increase of repolarization dispersion. The increased dose of echinochrome abolished the ischemic ECG repolarization changes but did not modify the incidence of ventricular arrhythmias. Conclusion: Echinochrome modified ischemi

Název v anglickém jazyce

Effects of Echinochrome on Ventricular Repolarization in Acute Ischemia

Popis výsledku anglicky

Background: Myocardial ischemic electrophysiological alterations are associated with the generation of reactive oxygen species. However, electrophysiological effects of antioxidants are unclear. Our objective was to determine the effects of the antioxidant echinochrome on ventricular repolarization in a feline model of 30-min ischemia. Methods and results: Activation recovery intervals were measured from 64 ventricular electrograms recorded before and during the LAD ligation in untreated animals (controls, n = 5) and animals given echinochrome (1 mg/kg, n = 5 and 2 mg/kg, n = 7). In controls, ischemia resulted in the increase of repolarization dispersion, QTc and Tpeak Tend intervals and precordial T wave amplitude dispersion. Echinochrome attenuated the ischemic increase of repolarization dispersion. The increased dose of echinochrome abolished the ischemic ECG repolarization changes but did not modify the incidence of ventricular arrhythmias. Conclusion: Echinochrome modified ischemi

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

ED - Fyziologie

OECD FORD obor

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Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Electrocardiology

ISSN

0022-0736

e-ISSN

—

Svazek periodika

48

Číslo periodika v rámci svazku

2

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

6

Strana od-do

181-186

Kód UT WoS článku

000353075600009

EID výsledku v databázi Scopus

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