The MATLAB Toolbox for Animal 3D Brain Mapping and Significant Probability Mapping

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68407700%3A21460%2F18%3A00331241" target="_blank" >RIV/68407700:21460/18:00331241 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

The MATLAB Toolbox for Animal 3D Brain Mapping and Significant Probability Mapping

Popis výsledku v původním jazyce

Measurements on animals are important in pre-clinical practice. The aim of our study was to develop a software module for animal brain-mapping. Topographical maps are an excellent and nearly ubiquitously used method for showing the spatial distribution of EEG results. In open literature, EEG measurement on animal models has not a standardized system. Adaptive system for the 3D brain-mapping, that we developed, is in animal research necessary. In MATLAB software we developed toolbox called BRAINBOX to perform 3D brain-mapping technique via 3D spline algorithm and via spherical spline algorithm. We used brain model of Wistar rat from BAR atlas for testing purpose. Our results showed that the 3D spline interpolation method with the projection on sphere gives significantly better 3D potential map than spherical spline interpolation method. The module for significant probability mapping (SPM) was successfully implemented. We tested this module by using RANOVA and baseline correction for two parameters: the absolute power and the relative power, both in the frequency range from 1 Hz to 50 Hz with 1 Hz step. We tested this utility in pharmaco-EEG in Wistar rats. Using this module, we proofed that there are significant differences after administration of psilocin to Wistar rats.

Název v anglickém jazyce

The MATLAB Toolbox for Animal 3D Brain Mapping and Significant Probability Mapping

Popis výsledku anglicky

Measurements on animals are important in pre-clinical practice. The aim of our study was to develop a software module for animal brain-mapping. Topographical maps are an excellent and nearly ubiquitously used method for showing the spatial distribution of EEG results. In open literature, EEG measurement on animal models has not a standardized system. Adaptive system for the 3D brain-mapping, that we developed, is in animal research necessary. In MATLAB software we developed toolbox called BRAINBOX to perform 3D brain-mapping technique via 3D spline algorithm and via spherical spline algorithm. We used brain model of Wistar rat from BAR atlas for testing purpose. Our results showed that the 3D spline interpolation method with the projection on sphere gives significantly better 3D potential map than spherical spline interpolation method. The module for significant probability mapping (SPM) was successfully implemented. We tested this module by using RANOVA and baseline correction for two parameters: the absolute power and the relative power, both in the frequency range from 1 Hz to 50 Hz with 1 Hz step. We tested this utility in pharmaco-EEG in Wistar rats. Using this module, we proofed that there are significant differences after administration of psilocin to Wistar rats.

Druh

O - Ostatní výsledky

CEP obor

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OECD FORD obor

10201 - Computer sciences, information science, bioinformathics (hardware development to be 2.2, social aspect to be 5.8)

Projekt

<a href="/cs/project/GA17-20480S" target="_blank" >GA17-20480S: Časový kontext v úloze analýzy dlouhodobého nestacionárního vícerozměrného signálu</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2018

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů