Calcium phosphate incorporated bacterial cellulose-polyvinylpyrrolidone based hydrogel scaffold: Structural property and cell viability study for bone regeneration application

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F70883521%3A28110%2F19%3A63523895" target="_blank" >RIV/70883521:28110/19:63523895 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/70883521:28610/19:63523895

Výsledek na webu

<a href="https://www.mdpi.com/2073-4360/11/11/1821" target="_blank" >https://www.mdpi.com/2073-4360/11/11/1821</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3390/polym11111821" target="_blank" >10.3390/polym11111821</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Calcium phosphate incorporated bacterial cellulose-polyvinylpyrrolidone based hydrogel scaffold: Structural property and cell viability study for bone regeneration application

Popis výsledku v původním jazyce

This work focuses on the analysis of structural and functional properties of calcium phosphate (CaP) incorporated bacterial cellulose (BC)-polyvinylpyrrolidone (PVP) based hydrogel scaffolds referred to as &quot;CaP/BC-PVP&quot;. CaP is incorporated in the scaffolds in the form of hydroxyapatite (HA) and beta-tricalcium phosphate (beta-TCP) in different concentrations (beta-TCP: HA (w/w) = 20:80, 40:60, and 50:50). The scaffolds were characterized on the basis of porosity, thermal, biodegradation, mechanical, and cell viability/cytocompatibility properties. The structural properties of all the hydrogel scaffolds show significant porosity. The biodegradation of &quot;CaP/BC-PVP&quot; scaffold was evaluated following hydrolytic degradation. Weight loss profile, pH change, scanning electron microscopy (SEM), and Fourier Transform Infrared Spectroscopy (FTIR) study confirm the significant degradability of the scaffolds. It is observed that a 50:50_CaP/BC-PVP scaffold has the highest degree of degradation. On the other hand, the compressive strengths of CaP/BC-PVP hydrogel scaffolds are found between 0.21 to 0.31 MPa, which is comparable with the human trabecular bone. The cell viability study is performed with a human osteosarcoma Saos-2 cell line, where significant cell viability is observed in all the hydrogel scaffolds. This indicated their ability to facilitate cell growth and cell proliferation. Considering all these substantial properties, CaP/BC-PVP hydrogel scaffolds can be suggested for detailed investigation in the context of bone regeneration application.

Název v anglickém jazyce

Calcium phosphate incorporated bacterial cellulose-polyvinylpyrrolidone based hydrogel scaffold: Structural property and cell viability study for bone regeneration application

Popis výsledku anglicky

This work focuses on the analysis of structural and functional properties of calcium phosphate (CaP) incorporated bacterial cellulose (BC)-polyvinylpyrrolidone (PVP) based hydrogel scaffolds referred to as &quot;CaP/BC-PVP&quot;. CaP is incorporated in the scaffolds in the form of hydroxyapatite (HA) and beta-tricalcium phosphate (beta-TCP) in different concentrations (beta-TCP: HA (w/w) = 20:80, 40:60, and 50:50). The scaffolds were characterized on the basis of porosity, thermal, biodegradation, mechanical, and cell viability/cytocompatibility properties. The structural properties of all the hydrogel scaffolds show significant porosity. The biodegradation of &quot;CaP/BC-PVP&quot; scaffold was evaluated following hydrolytic degradation. Weight loss profile, pH change, scanning electron microscopy (SEM), and Fourier Transform Infrared Spectroscopy (FTIR) study confirm the significant degradability of the scaffolds. It is observed that a 50:50_CaP/BC-PVP scaffold has the highest degree of degradation. On the other hand, the compressive strengths of CaP/BC-PVP hydrogel scaffolds are found between 0.21 to 0.31 MPa, which is comparable with the human trabecular bone. The cell viability study is performed with a human osteosarcoma Saos-2 cell line, where significant cell viability is observed in all the hydrogel scaffolds. This indicated their ability to facilitate cell growth and cell proliferation. Considering all these substantial properties, CaP/BC-PVP hydrogel scaffolds can be suggested for detailed investigation in the context of bone regeneration application.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10404 - Polymer science

Projekt

<a href="/cs/project/LO1504" target="_blank" >LO1504: Centrum polymerních systémů plus</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2019

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Polymers

ISSN

2073-4360

e-ISSN

—

Svazek periodika

11

Číslo periodika v rámci svazku

11

Stát vydavatele periodika

CH - Švýcarská konfederace

Počet stran výsledku

24

Strana od-do

—

Kód UT WoS článku

000503279200094

EID výsledku v databázi Scopus

2-s2.0-85075547311