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Cross-linked gelatine by modified dextran as a potential bioink prepared by a simple and non-toxic process

Identifikátory výsledku

  • Kód výsledku v IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F70883521%3A28110%2F22%3A63550758" target="_blank" >RIV/70883521:28110/22:63550758 - isvavai.cz</a>

  • Nalezeny alternativní kódy

    RIV/70883521:28140/22:63550758 RIV/70883521:28610/22:63550758

  • Výsledek na webu

    <a href="https://www.mdpi.com/2073-4360/14/3/391" target="_blank" >https://www.mdpi.com/2073-4360/14/3/391</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.3390/polym14030391" target="_blank" >10.3390/polym14030391</a>

Alternativní jazyky

  • Jazyk výsledku

    angličtina

  • Název v původním jazyce

    Cross-linked gelatine by modified dextran as a potential bioink prepared by a simple and non-toxic process

  • Popis výsledku v původním jazyce

    Essential features of well-designed materials intended for 3D bioprinting via microex-trusion are the appropriate rheological behavior and cell-friendly environment. Despite the rapid development, few materials are utilizable as bioinks. The aim of our work was to design a novel cytocompatible material facilitating extrusion-based 3D printing while maintaining a relatively simple and straightforward preparation process without the need for harsh chemicals or radiation. Specifically, hydrogels were prepared from gelatines coming from three sources—bovine, rabbit, and chicken—cross-linked by dextran polyaldehyde. The influence of dextran concentration on the properties of hydrogels was studied. Rheological measurements not only confirmed the strong shear-thinning behavior of prepared inks but were also used for capturing cross-linking reaction kinetics and demonstrated quick achievement of gelation point (in most cases &lt; 3 min). Their viscoelastic properties allowed satisfactory extrusion, forming a self-supported multi-layered uniformly porous structure. All gelatin-based hydrogels were non-cytototoxic. Homogeneous cells distribution within the printed scaffold was confirmed by fluorescence confocal microscopy. In addition, no disruption of cells structure was observed. The results demonstrate the great potential of the presented hydrogels for applications related to 3D bioprinting.

  • Název v anglickém jazyce

    Cross-linked gelatine by modified dextran as a potential bioink prepared by a simple and non-toxic process

  • Popis výsledku anglicky

    Essential features of well-designed materials intended for 3D bioprinting via microex-trusion are the appropriate rheological behavior and cell-friendly environment. Despite the rapid development, few materials are utilizable as bioinks. The aim of our work was to design a novel cytocompatible material facilitating extrusion-based 3D printing while maintaining a relatively simple and straightforward preparation process without the need for harsh chemicals or radiation. Specifically, hydrogels were prepared from gelatines coming from three sources—bovine, rabbit, and chicken—cross-linked by dextran polyaldehyde. The influence of dextran concentration on the properties of hydrogels was studied. Rheological measurements not only confirmed the strong shear-thinning behavior of prepared inks but were also used for capturing cross-linking reaction kinetics and demonstrated quick achievement of gelation point (in most cases &lt; 3 min). Their viscoelastic properties allowed satisfactory extrusion, forming a self-supported multi-layered uniformly porous structure. All gelatin-based hydrogels were non-cytototoxic. Homogeneous cells distribution within the printed scaffold was confirmed by fluorescence confocal microscopy. In addition, no disruption of cells structure was observed. The results demonstrate the great potential of the presented hydrogels for applications related to 3D bioprinting.

Klasifikace

  • Druh

    J<sub>imp</sub> - Článek v periodiku v databázi Web of Science

  • CEP obor

  • OECD FORD obor

    10404 - Polymer science

Návaznosti výsledku

  • Projekt

    <a href="/cs/project/GA20-28732S" target="_blank" >GA20-28732S: Koloidní systémy pro topické formulace. Pickeringovy emulze a koloidy na bázi polymerů.</a><br>

  • Návaznosti

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Ostatní

  • Rok uplatnění

    2022

  • Kód důvěrnosti údajů

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Údaje specifické pro druh výsledku

  • Název periodika

    Polymers

  • ISSN

    2073-4360

  • e-ISSN

  • Svazek periodika

    14

  • Číslo periodika v rámci svazku

    3

  • Stát vydavatele periodika

    CH - Švýcarská konfederace

  • Počet stran výsledku

    16

  • Strana od-do

    nestrankovano

  • Kód UT WoS článku

    000754557300001

  • EID výsledku v databázi Scopus

    2-s2.0-85123200312