Structuring of silk-fibroin surfaces by phase separation

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F70883521%3A28110%2F22%3A63557720" target="_blank" >RIV/70883521:28110/22:63557720 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/70883521:28610/22:63557720

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Structuring of silk-fibroin surfaces by phase separation

Popis výsledku v původním jazyce

Silk protein (Bombyx mori) surfaces are characterized by poor cell adhesion, hence additional surface treatments are required in order to create structured surfaces to increase the adhesive capabilities of selected cell lines. To solve this problem, surface treatment procedures use either patterning templates or preparation of polymer blends. Phase separation procedures are rather rare. In this study, silk protein-based coatings were structured by a dropwise addition of solvent/non solvent mixtures. A special device was developed to create controlled physical conditions during the multi-step, timesequenced surface treatment. The process parameters for the surface modification were optimized to control the texture formation from nano- up to microporous structures. The interaction of different cell lines was studied on the textured surfaces to explore their application scope in biomedical applications.

Název v anglickém jazyce

Structuring of silk-fibroin surfaces by phase separation

Popis výsledku anglicky

Silk protein (Bombyx mori) surfaces are characterized by poor cell adhesion, hence additional surface treatments are required in order to create structured surfaces to increase the adhesive capabilities of selected cell lines. To solve this problem, surface treatment procedures use either patterning templates or preparation of polymer blends. Phase separation procedures are rather rare. In this study, silk protein-based coatings were structured by a dropwise addition of solvent/non solvent mixtures. A special device was developed to create controlled physical conditions during the multi-step, timesequenced surface treatment. The process parameters for the surface modification were optimized to control the texture formation from nano- up to microporous structures. The interaction of different cell lines was studied on the textured surfaces to explore their application scope in biomedical applications.

Druh

O - Ostatní výsledky

CEP obor

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OECD FORD obor

20506 - Coating and films

Projekt

<a href="/cs/project/GA22-33307S" target="_blank" >GA22-33307S: Vývoj nových 3D hierarchicky strukturovaných polysacharidových a proteinových porézních systémů</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2022

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů