Atom transfer radical polymerization of 2-isopropenyl-2-oxazoline in solution and from the surface of carbonyl iron particles toward fabrication of a cytocompatible magneto-responsive hybrid filler

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F70883521%3A28110%2F23%3A63569218" target="_blank" >RIV/70883521:28110/23:63569218 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/70883521:28610/23:63569218

Výsledek na webu

<a href="https://pubs.acs.org/doi/10.1021/acs.macromol.3c00400" target="_blank" >https://pubs.acs.org/doi/10.1021/acs.macromol.3c00400</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1021/acs.macromol.3c00400" target="_blank" >10.1021/acs.macromol.3c00400</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Atom transfer radical polymerization of 2-isopropenyl-2-oxazoline in solution and from the surface of carbonyl iron particles toward fabrication of a cytocompatible magneto-responsive hybrid filler

Popis výsledku v původním jazyce

Atom transfer radical polymerization (ATRP) of 2-isopropenyl-2-oxazoline was optimized both in solution and initiated from carbonyl iron (CI) particle surface (SI-ATRP) in order to obtain polymers with well-defined molar mass and narrow dispersity. The polymerization procedure was thoroughly investigated by size exclusion chromatography and H-1 NMR and optimized from the point of view type of initiator, ligand, copper catalyst, and solvent. Finally, the poly-(2-isopropenyl-2-oxazoline)(PIPOx) with controlled molar masses up to 20,000 g/mol and dispersity in the range of 1.2-1.5 were successfully prepared, while high conversions could be reached. Polymerization conditions using halogen exchange leading to well-defined PIPOx were also developed and used for SI-ATRP. SI-ATRP was finally applied for synthesis of magnetic CI-PIPOx core-shell particles with two various molar masses of the grafted PIPOx. Finally, as a proof of applicability of such hybrid particles, the particles were dispersed in the phosphate buffer saline and glycerol to obtain the magnetorheological fluid with blood-like characteristics. Magnetorheological and cytotoxicity investigations proved that non-cytotoxic CI-PIPOx core-shell particles provided the system with sufficient yield stress values to act as an embolization agent.

Název v anglickém jazyce

Atom transfer radical polymerization of 2-isopropenyl-2-oxazoline in solution and from the surface of carbonyl iron particles toward fabrication of a cytocompatible magneto-responsive hybrid filler

Popis výsledku anglicky

Atom transfer radical polymerization (ATRP) of 2-isopropenyl-2-oxazoline was optimized both in solution and initiated from carbonyl iron (CI) particle surface (SI-ATRP) in order to obtain polymers with well-defined molar mass and narrow dispersity. The polymerization procedure was thoroughly investigated by size exclusion chromatography and H-1 NMR and optimized from the point of view type of initiator, ligand, copper catalyst, and solvent. Finally, the poly-(2-isopropenyl-2-oxazoline)(PIPOx) with controlled molar masses up to 20,000 g/mol and dispersity in the range of 1.2-1.5 were successfully prepared, while high conversions could be reached. Polymerization conditions using halogen exchange leading to well-defined PIPOx were also developed and used for SI-ATRP. SI-ATRP was finally applied for synthesis of magnetic CI-PIPOx core-shell particles with two various molar masses of the grafted PIPOx. Finally, as a proof of applicability of such hybrid particles, the particles were dispersed in the phosphate buffer saline and glycerol to obtain the magnetorheological fluid with blood-like characteristics. Magnetorheological and cytotoxicity investigations proved that non-cytotoxic CI-PIPOx core-shell particles provided the system with sufficient yield stress values to act as an embolization agent.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10404 - Polymer science

Projekt

—

Návaznosti

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Rok uplatnění

2023

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Macromolecules

ISSN

0024-9297

e-ISSN

—

Svazek periodika

56

Číslo periodika v rámci svazku

11

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

9

Strana od-do

3904-3912

Kód UT WoS článku

001010456800001

EID výsledku v databázi Scopus

2-s2.0-85163363888