Carbonyl Iron Grafted with 2-Isopropenyl-2-oxazoline under Atom Transfer Radical Polymerization Conditions in Solution

Kód výsledku v IS VaVaI

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RIV/70883521:28610/23:63571039

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Carbonyl Iron Grafted with 2-Isopropenyl-2-oxazoline under Atom Transfer Radical Polymerization Conditions in Solution

Popis výsledku v původním jazyce

The poly(2-isopropenyl-2-oxazoline) (PIPOx) is considered as a promising polymer for biomedical applications. The in-vitro cytotoxicity measurements and ex-vivo proliferation tests proved non-cytotoxicity of PIPOx. IPOx monomer provides two polymerizable groups, the vinyl and 2-oxazoline unit. In this study the attention was paid to polymerization using the vinyl group. The utilization of ATRP technique allows to obtain the well-defined polymers. However, the attempts to polymerize IPOx under traditional ATRP conditions were described as unsuccessful due to strong complexation of pendant 2-oxazoline group with copper catalyst. In this contribution it is shown that IPOx can be polymerized under ATRP conditions when copper bromide is replaced with copper chloride. In addition, the surface-initiated ATRP from the carbonyl iron (CI) particles was employed by halogen exchange method for the first time. The fabricated CI-PIPOx hybrids were thoroughly characterized and both magnetorheological capabilities of the hybrid particles in blood-like medium as well as their cytocompatibility behaviour showed promising results for possible application as embolization agent.

Název v anglickém jazyce

Carbonyl Iron Grafted with 2-Isopropenyl-2-oxazoline under Atom Transfer Radical Polymerization Conditions in Solution

Popis výsledku anglicky

The poly(2-isopropenyl-2-oxazoline) (PIPOx) is considered as a promising polymer for biomedical applications. The in-vitro cytotoxicity measurements and ex-vivo proliferation tests proved non-cytotoxicity of PIPOx. IPOx monomer provides two polymerizable groups, the vinyl and 2-oxazoline unit. In this study the attention was paid to polymerization using the vinyl group. The utilization of ATRP technique allows to obtain the well-defined polymers. However, the attempts to polymerize IPOx under traditional ATRP conditions were described as unsuccessful due to strong complexation of pendant 2-oxazoline group with copper catalyst. In this contribution it is shown that IPOx can be polymerized under ATRP conditions when copper bromide is replaced with copper chloride. In addition, the surface-initiated ATRP from the carbonyl iron (CI) particles was employed by halogen exchange method for the first time. The fabricated CI-PIPOx hybrids were thoroughly characterized and both magnetorheological capabilities of the hybrid particles in blood-like medium as well as their cytocompatibility behaviour showed promising results for possible application as embolization agent.

Druh

O - Ostatní výsledky

CEP obor

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OECD FORD obor

10404 - Polymer science

Projekt

<a href="/cs/project/NU23-08-00243" target="_blank" >NU23-08-00243: Funkční náhrady pro regeneraci nervových tkání připravované pomocí pokročilých 3D tiskových technik</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2023

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů