Morphological Characterization of Polycaprolactone Spherulites in Silk-PCL Mixtures: Implications for 3D Printing of Textured Scaffolds in Tissue Engineering

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F70883521%3A28110%2F24%3A63577618" target="_blank" >RIV/70883521:28110/24:63577618 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/70883521:28610/24:63577618

Výsledek na webu

—

DOI - Digital Object Identifier

—

Jazyk výsledku

angličtina

Název v původním jazyce

Morphological Characterization of Polycaprolactone Spherulites in Silk-PCL Mixtures: Implications for 3D Printing of Textured Scaffolds in Tissue Engineering

Popis výsledku v původním jazyce

This study investigates the synergistic integration of silk protein and polycaprolactone (PCL) in blends derived from distinct solvents, with the primary aim of enhancing the biocompatibility of PCL and preparing a mixture suitable for 3D printing of surface-textured scaffolds.[1,2] The research explores the interaction between silk protein and PCL, revealing crucial insights into their morphological transformations and structural changes. The formation of silk protein particles in the mixture with PCL has been observed. These particles exert a profound influence on the spherulitic structure of PCL, with significant changes occurring at various concentrations. At low concentrations of silk protein, a ring-banded structure emerges, reshaping the traditional spherulites associated with PCL.[3] As the concentration of silk protein increases in the mixture, there is a gradual disappearance of spherulites, ultimately leading to the formation of a pit-patterned surface in the case of a majority contribution of silk protein in the blend. These observations underscore the influence of silk protein in modulating the surface properties of PCL blends, presenting new opportunities for tailoring material characteristics in 3D printing applications for tissue engineering.

Název v anglickém jazyce

Morphological Characterization of Polycaprolactone Spherulites in Silk-PCL Mixtures: Implications for 3D Printing of Textured Scaffolds in Tissue Engineering

Popis výsledku anglicky

This study investigates the synergistic integration of silk protein and polycaprolactone (PCL) in blends derived from distinct solvents, with the primary aim of enhancing the biocompatibility of PCL and preparing a mixture suitable for 3D printing of surface-textured scaffolds.[1,2] The research explores the interaction between silk protein and PCL, revealing crucial insights into their morphological transformations and structural changes. The formation of silk protein particles in the mixture with PCL has been observed. These particles exert a profound influence on the spherulitic structure of PCL, with significant changes occurring at various concentrations. At low concentrations of silk protein, a ring-banded structure emerges, reshaping the traditional spherulites associated with PCL.[3] As the concentration of silk protein increases in the mixture, there is a gradual disappearance of spherulites, ultimately leading to the formation of a pit-patterned surface in the case of a majority contribution of silk protein in the blend. These observations underscore the influence of silk protein in modulating the surface properties of PCL blends, presenting new opportunities for tailoring material characteristics in 3D printing applications for tissue engineering.

Druh

O - Ostatní výsledky

CEP obor

—

OECD FORD obor

20505 - Composites (including laminates, reinforced plastics, cermets, combined natural and synthetic fibre fabrics; filled composites)

Projekt

<a href="/cs/project/NU23-08-00243" target="_blank" >NU23-08-00243: Funkční náhrady pro regeneraci nervových tkání připravované pomocí pokročilých 3D tiskových technik</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2024

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů