Preparation, characterization and antibacterial activity of 1-monoacylglycerol of adamantane-1-carboxylic acid
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F70883521%3A28610%2F13%3A43870028" target="_blank" >RIV/70883521:28610/13:43870028 - isvavai.cz</a>
Nalezeny alternativní kódy
RIV/70883521:28110/13:43870028
Výsledek na webu
<a href="http://dx.doi.org/10.1111/jfbc.12005" target="_blank" >http://dx.doi.org/10.1111/jfbc.12005</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1111/jfbc.12005" target="_blank" >10.1111/jfbc.12005</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Preparation, characterization and antibacterial activity of 1-monoacylglycerol of adamantane-1-carboxylic acid
Popis výsledku v původním jazyce
A nontraditional monoacylglycerol, 1-monoacylglycerol of adamantane-1-carboxylic acid (2,3-dihydroxypropyl adamantane-1-carboxylate), has been prepared using the direct addition of adamantane-1-carboxylic acid to glycidol. Several reaction conditions were examined in order to improve the reaction yield. Based upon the results of these experiments, the following conditions were recommended: glycidol at 80% molar excess, molar ratio of the adamantane-1-carboxylic acid and toluene as a solvent 1:10, chromium (III) acetate hydroxide as a catalyst (0.5% w/w), 96C. Final reaction product with conversion higher than 98% was further analyzed using high-performance liquid chromatography, gas chromatography-mass spectrometry, nuclear magnetic resonance analysisand differential scanning calorimetry. The effect exhibited by 2,3-dihydroxypropyl adamantane-1-carboxylate against important species of Gram-positive and Gram-negative bacteria was assessed. Results showed that 2,3-dihydroxypropyl adaman
Název v anglickém jazyce
Preparation, characterization and antibacterial activity of 1-monoacylglycerol of adamantane-1-carboxylic acid
Popis výsledku anglicky
A nontraditional monoacylglycerol, 1-monoacylglycerol of adamantane-1-carboxylic acid (2,3-dihydroxypropyl adamantane-1-carboxylate), has been prepared using the direct addition of adamantane-1-carboxylic acid to glycidol. Several reaction conditions were examined in order to improve the reaction yield. Based upon the results of these experiments, the following conditions were recommended: glycidol at 80% molar excess, molar ratio of the adamantane-1-carboxylic acid and toluene as a solvent 1:10, chromium (III) acetate hydroxide as a catalyst (0.5% w/w), 96C. Final reaction product with conversion higher than 98% was further analyzed using high-performance liquid chromatography, gas chromatography-mass spectrometry, nuclear magnetic resonance analysisand differential scanning calorimetry. The effect exhibited by 2,3-dihydroxypropyl adamantane-1-carboxylate against important species of Gram-positive and Gram-negative bacteria was assessed. Results showed that 2,3-dihydroxypropyl adaman
Klasifikace
Druh
J<sub>x</sub> - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
CEP obor
EE - Mikrobiologie, virologie
OECD FORD obor
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Návaznosti výsledku
Projekt
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Návaznosti
Z - Vyzkumny zamer (s odkazem do CEZ)
Ostatní
Rok uplatnění
2013
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
JOURNAL OF FOOD BIOCHEMISTRY
ISSN
0145-8884
e-ISSN
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Svazek periodika
37
Číslo periodika v rámci svazku
5
Stát vydavatele periodika
US - Spojené státy americké
Počet stran výsledku
10
Strana od-do
544-553
Kód UT WoS článku
000325460300005
EID výsledku v databázi Scopus
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