Chitosan-DNA complexes: Effect of molecular parameters on the efficiency of delivery

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F70883521%3A28610%2F14%3A43871817" target="_blank" >RIV/70883521:28610/14:43871817 - isvavai.cz</a>

Výsledek na webu

<a href="http://www.sciencedirect.com/science/article/pii/S0927775713009394" target="_blank" >http://www.sciencedirect.com/science/article/pii/S0927775713009394</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.colsurfa.2013.12.022" target="_blank" >10.1016/j.colsurfa.2013.12.022</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Chitosan-DNA complexes: Effect of molecular parameters on the efficiency of delivery

Popis výsledku v původním jazyce

In the last few decades, there has been a growing interest towards the use of delivery systems for a more effective treatment of various diseases and the research increasingly focused on designing innovative solutions based on intra-cellular vectors. Among them, biocompatible DNA-polyelectrolyte complexes appear as a promising strategy for in vivo delivery of biologically active macromolecules. One of the most largely employed cationic polymer is Chitosan, which is special for its biological propertiessuch as biodegradability, biocompatibility, mucoadhesivity, and permeability enhancer capacity. Due to this, complexes formed by condensation of DNA by Chitosan have been largely investigated for their potential use in gene therapy. Nevertheless the extensive efforts, the correlation between the physicochemical properties of the Chitosan-DNA polyplexes with their transfection efficiency still remains a central challenge. Moreover, the criteria and strategies for the design of efficient C

Název v anglickém jazyce

Chitosan-DNA complexes: Effect of molecular parameters on the efficiency of delivery

Popis výsledku anglicky

In the last few decades, there has been a growing interest towards the use of delivery systems for a more effective treatment of various diseases and the research increasingly focused on designing innovative solutions based on intra-cellular vectors. Among them, biocompatible DNA-polyelectrolyte complexes appear as a promising strategy for in vivo delivery of biologically active macromolecules. One of the most largely employed cationic polymer is Chitosan, which is special for its biological propertiessuch as biodegradability, biocompatibility, mucoadhesivity, and permeability enhancer capacity. Due to this, complexes formed by condensation of DNA by Chitosan have been largely investigated for their potential use in gene therapy. Nevertheless the extensive efforts, the correlation between the physicochemical properties of the Chitosan-DNA polyplexes with their transfection efficiency still remains a central challenge. Moreover, the criteria and strategies for the design of efficient C

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

CD - Makromolekulární chemie

OECD FORD obor

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Projekt

—

Návaznosti

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Rok uplatnění

2014

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Colloids and Surfaces A: Physicochemical and Engineering Aspects

ISSN

0927-7757

e-ISSN

—

Svazek periodika

460

Číslo periodika v rámci svazku

Neuveden

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

7

Strana od-do

184-190

Kód UT WoS článku

000341880200025

EID výsledku v databázi Scopus

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