Smart polysaccharides nanoparticles for controlled release of protein

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F70883521%3A28610%2F16%3A43875560" target="_blank" >RIV/70883521:28610/16:43875560 - isvavai.cz</a>

Výsledek na webu

—

DOI - Digital Object Identifier

—

Jazyk výsledku

angličtina

Název v původním jazyce

Smart polysaccharides nanoparticles for controlled release of protein

Popis výsledku v původním jazyce

Polysaccharides based nanoparticles have been thoroughly investigated for controlled release of therapeutic molecules. The ability to regulate the release rate according to the environment at the target site represents one of the main interests in drug delivery field. The aim of this work was to prepare and characterize the pH and ionic strength sensitive chitosan-dextran sulfate based nanoparticles loaded with two model proteins, bovine serum albumin and trypsin (TRY), respectively. Nanoparticles showed size in the range 120-250 nm, positive zeta potential (20-35 mV), stability and high loading capacity, up to 800g of protein per mg of nanoparticles. The release kinetics of the both proteins was significantly influenced by the external media properties. Furthemore, the initial burst effect reduction in physiological medi was reduced.

Název v anglickém jazyce

Smart polysaccharides nanoparticles for controlled release of protein

Popis výsledku anglicky

Polysaccharides based nanoparticles have been thoroughly investigated for controlled release of therapeutic molecules. The ability to regulate the release rate according to the environment at the target site represents one of the main interests in drug delivery field. The aim of this work was to prepare and characterize the pH and ionic strength sensitive chitosan-dextran sulfate based nanoparticles loaded with two model proteins, bovine serum albumin and trypsin (TRY), respectively. Nanoparticles showed size in the range 120-250 nm, positive zeta potential (20-35 mV), stability and high loading capacity, up to 800g of protein per mg of nanoparticles. The release kinetics of the both proteins was significantly influenced by the external media properties. Furthemore, the initial burst effect reduction in physiological medi was reduced.

Druh

O - Ostatní výsledky

CEP obor

JI - Kompositní materiály

OECD FORD obor

—

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2016

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů