Chitosan-whey protein isolate core-shell nanoparticles as delivery systems
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F70883521%3A28610%2F23%3A63574720" target="_blank" >RIV/70883521:28610/23:63574720 - isvavai.cz</a>
Výsledek na webu
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DOI - Digital Object Identifier
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Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Chitosan-whey protein isolate core-shell nanoparticles as delivery systems
Popis výsledku v původním jazyce
Whey protein isolate (WPI), employed as a camer for a wide range of bioactive substances, suffers from a lack of colloidal stability in physiological conditions. Herein, we developed innovative stabilized Poly Electrolyte Nanoparticles (PENs) obtained by two techniques: polyelectrolyte complexation of negatively charged WPI and positively charged chitosan (GS), and ionic gelation in the presence of polyanion tripolyphosphate (TPP). Therefore, the WPl-based core was coated with a CS-based shell and then stabilized by TPP al pH 8. The nanostructures were characterized by physiochemical methods, and lheir encapsulation efficiency and in vitro release were evaluated. The spherical NPs with an average size of 248. 57 ± 5.00 nm and surface charge of +10.80 ± 0.43 mV demonstrated high encapsulation efficiency (92. 79 ± 0.69) and sustained release of a positively charged chemotherapeutic agent of doxorubicin (DOX) as model drug .
Název v anglickém jazyce
Chitosan-whey protein isolate core-shell nanoparticles as delivery systems
Popis výsledku anglicky
Whey protein isolate (WPI), employed as a camer for a wide range of bioactive substances, suffers from a lack of colloidal stability in physiological conditions. Herein, we developed innovative stabilized Poly Electrolyte Nanoparticles (PENs) obtained by two techniques: polyelectrolyte complexation of negatively charged WPI and positively charged chitosan (GS), and ionic gelation in the presence of polyanion tripolyphosphate (TPP). Therefore, the WPl-based core was coated with a CS-based shell and then stabilized by TPP al pH 8. The nanostructures were characterized by physiochemical methods, and lheir encapsulation efficiency and in vitro release were evaluated. The spherical NPs with an average size of 248. 57 ± 5.00 nm and surface charge of +10.80 ± 0.43 mV demonstrated high encapsulation efficiency (92. 79 ± 0.69) and sustained release of a positively charged chemotherapeutic agent of doxorubicin (DOX) as model drug .
Klasifikace
Druh
O - Ostatní výsledky
CEP obor
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OECD FORD obor
20903 - Bioproducts (products that are manufactured using biological material as feedstock) biomaterials, bioplastics, biofuels, bioderived bulk and fine chemicals, bio-derived novel materials
Návaznosti výsledku
Projekt
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Návaznosti
V - Vyzkumna aktivita podporovana z jinych verejnych zdroju
Ostatní
Rok uplatnění
2023
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů