Evaluation of scan strategies for small animal in vivo micro-CT

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F86652052%3A_____%2F20%3AN0000015" target="_blank" >RIV/86652052:_____/20:N0000015 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/68407700:21670/20:00346494 RIV/00216208:11120/20:43919710

Výsledek na webu

<a href="https://iopscience.iop.org/article/10.1088/1748-0221/15/02/C02019/meta" target="_blank" >https://iopscience.iop.org/article/10.1088/1748-0221/15/02/C02019/meta</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1088/1748-0221/15/02/C02019" target="_blank" >10.1088/1748-0221/15/02/C02019</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Evaluation of scan strategies for small animal in vivo micro-CT

Popis výsledku v původním jazyce

The micro-CT scanners of the radiography laboratories at the Institute of Experimental and Applied Physics (IEAP) have been used many times for post mortem imaging of small animals. The systems are based on the Timepix detector technology and they can provide CT models with spatial resolution up to few micrometres for such samples. Until now the investigated samples were ex vivo organs or small animals and image quality was a key parameter of these scans. The transition to the in vivo measurement is connected with the limitation of the absorbed dose in the investigated sample. Pilot measurements with the thermoluminescent dosimeters (TLD) were performed and the dose rate for a small rodent was estimated. This dose rate limits the maximal irradiation time for live specimens to tens of seconds to avoid immunosuppression or other irreversible biological damages. Series of measurements were performed with PlastiMouseTM phantom using different acquisition parameters to evaluate best data acquisition strategy for given dose limits. The presented data refers to the relationship between exposure time recorded by the detector and the reconstructed micro-CT slices quality. Contrast-to-noise ratio was evaluated for 112 selected combinations of acquisition times and angular sampling. This covers a range of sample doses from 50 to 4500 mGy delivered during recorded exposure time.

Název v anglickém jazyce

Evaluation of scan strategies for small animal in vivo micro-CT

Popis výsledku anglicky

The micro-CT scanners of the radiography laboratories at the Institute of Experimental and Applied Physics (IEAP) have been used many times for post mortem imaging of small animals. The systems are based on the Timepix detector technology and they can provide CT models with spatial resolution up to few micrometres for such samples. Until now the investigated samples were ex vivo organs or small animals and image quality was a key parameter of these scans. The transition to the in vivo measurement is connected with the limitation of the absorbed dose in the investigated sample. Pilot measurements with the thermoluminescent dosimeters (TLD) were performed and the dose rate for a small rodent was estimated. This dose rate limits the maximal irradiation time for live specimens to tens of seconds to avoid immunosuppression or other irreversible biological damages. Series of measurements were performed with PlastiMouseTM phantom using different acquisition parameters to evaluate best data acquisition strategy for given dose limits. The presented data refers to the relationship between exposure time recorded by the detector and the reconstructed micro-CT slices quality. Contrast-to-noise ratio was evaluated for 112 selected combinations of acquisition times and angular sampling. This covers a range of sample doses from 50 to 4500 mGy delivered during recorded exposure time.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

20602 - Medical laboratory technology (including laboratory samples analysis; diagnostic technologies) (Biomaterials to be 2.9 [physical characteristics of living material as related to medical implants, devices, sensors])

Projekt

<a href="/cs/project/EF16_019%2F0000766" target="_blank" >EF16_019/0000766: Inženýrské aplikace fyziky mikrosvěta</a><br>

Návaznosti

O - Projekt operacniho programu

Rok uplatnění

2020

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Instrumentation

ISSN

1748-0221

e-ISSN

—

Svazek periodika

15

Číslo periodika v rámci svazku

5

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

7

Strana od-do

C02019

Kód UT WoS článku

000527943500019

EID výsledku v databázi Scopus

2-s2.0-85081610080