Dynamic changes of B-cell compartments in kidney transplantation: lack of transitional B cells is associated with allograft rejection

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F16%3A00059999" target="_blank" >RIV/00023001:_____/16:00059999 - isvavai.cz</a>

Výsledek na webu

<a href="http://onlinelibrary.wiley.com/doi/10.1111/tri.12751/epdf" target="_blank" >http://onlinelibrary.wiley.com/doi/10.1111/tri.12751/epdf</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1111/tri.12751" target="_blank" >10.1111/tri.12751</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Dynamic changes of B-cell compartments in kidney transplantation: lack of transitional B cells is associated with allograft rejection

Popis výsledku v původním jazyce

B cells play an important role in the immune responses which affect the outcomes of kidney allografts. Dynamic changes of B-cell compartments in clinical kidney transplantation are still poorly understood. B-cell subsets were prospectively monitored using flow cytometry for 1 year in 98 kidney transplant recipients. Data were correlated with immunosuppression and clinical outcomes. An increase in the total population of B lymphocytes was observed during the first week after transplantation. The level of IgM(high)CD38(high)CD24(high) transitional B cells reduced significantly up until the third month, with partial repopulation in the first year. Lower numbers of transitional B cells in the third month were associated with higher risk of graft rejection. IgM(+)IgD(+)CD27(-) naive B cells did not change within follow-up. IgM(+)CD27(+) nonswitched memory B cells and IgM(-)CD27(+) switched memory B cells increased on post-operative day 7. IgM(-)CD38(high)CD27(high) plasmablasts showed similar kinetics during the first post-transplant year, similar to transitional B cells. In conclusion, sensitized kidney transplant recipients as well as those with either acute or chronic rejection within the first post-transplant year exhibited lower levels of transitional B cells. Therefore, these data further support the hypothesis that transitional B cells have a protective role in kidney transplantation.

Název v anglickém jazyce

Dynamic changes of B-cell compartments in kidney transplantation: lack of transitional B cells is associated with allograft rejection

Popis výsledku anglicky

B cells play an important role in the immune responses which affect the outcomes of kidney allografts. Dynamic changes of B-cell compartments in clinical kidney transplantation are still poorly understood. B-cell subsets were prospectively monitored using flow cytometry for 1 year in 98 kidney transplant recipients. Data were correlated with immunosuppression and clinical outcomes. An increase in the total population of B lymphocytes was observed during the first week after transplantation. The level of IgM(high)CD38(high)CD24(high) transitional B cells reduced significantly up until the third month, with partial repopulation in the first year. Lower numbers of transitional B cells in the third month were associated with higher risk of graft rejection. IgM(+)IgD(+)CD27(-) naive B cells did not change within follow-up. IgM(+)CD27(+) nonswitched memory B cells and IgM(-)CD27(+) switched memory B cells increased on post-operative day 7. IgM(-)CD38(high)CD27(high) plasmablasts showed similar kinetics during the first post-transplant year, similar to transitional B cells. In conclusion, sensitized kidney transplant recipients as well as those with either acute or chronic rejection within the first post-transplant year exhibited lower levels of transitional B cells. Therefore, these data further support the hypothesis that transitional B cells have a protective role in kidney transplantation.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FJ - Chirurgie včetně transplantologie

OECD FORD obor

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Projekt

<a href="/cs/project/NT14102" target="_blank" >NT14102: Role B lymfocytů v imunitních reakcích po transplantaci ledviny</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2016

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Transplant international

ISSN

0934-0874

e-ISSN

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Svazek periodika

29

Číslo periodika v rámci svazku

5

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

9

Strana od-do

540-548

Kód UT WoS článku

000375064100004

EID výsledku v databázi Scopus

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