Putativní linie embryonálních kmenových buněk z prasečích embryí

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00027014%3A_____%2F07%3A%230000539" target="_blank" >RIV/00027014:_____/07:#0000539 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Putative embryonic stem cell lines from pig embryos

Popis výsledku v původním jazyce

Embryonic stem cells (ES cells) represent a population of pluripotent, undifferentiated cells derived from early embryos that are capable of proliferating without any limitation in an undifferentiated state, and when injected into blastocysts, they can participate in the formation of all tissues. It is possible to transfect them with a gene of interest, and the resulting transgenic cell lines can also be used for production of chimeras. Before application of stem cell therapies into a human medicine, itis necessary to verify these methods with an acceptable animal model. The pig is currently used for pre-clinical applications, and therefore establishment of porcine ES cell lines is highly needed; unfortunately, no convincing ES cell lines have been produced in this species (and other domestic animals) to date. We discuss the recent advances in this field, especially oriented on possible reasons and obstacles why derivation of porcine ES cell lines is still unsuccessful.

Název v anglickém jazyce

Putative embryonic stem cell lines from pig embryos

Popis výsledku anglicky

Embryonic stem cells (ES cells) represent a population of pluripotent, undifferentiated cells derived from early embryos that are capable of proliferating without any limitation in an undifferentiated state, and when injected into blastocysts, they can participate in the formation of all tissues. It is possible to transfect them with a gene of interest, and the resulting transgenic cell lines can also be used for production of chimeras. Before application of stem cell therapies into a human medicine, itis necessary to verify these methods with an acceptable animal model. The pig is currently used for pre-clinical applications, and therefore establishment of porcine ES cell lines is highly needed; unfortunately, no convincing ES cell lines have been produced in this species (and other domestic animals) to date. We discuss the recent advances in this field, especially oriented on possible reasons and obstacles why derivation of porcine ES cell lines is still unsuccessful.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

EB - Genetika a molekulární biologie

OECD FORD obor

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Projekt

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Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2007

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Reproduction and Development

ISSN

0916-8818

e-ISSN

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Svazek periodika

53

Číslo periodika v rámci svazku

6

Stát vydavatele periodika

JP - Japonsko

Počet stran výsledku

13

Strana od-do

1137-1149

Kód UT WoS článku

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EID výsledku v databázi Scopus

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