Androgen receptor inhibitor stimulates telomerase activity of pig granulosa cells in vitro

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00027014%3A_____%2F11%3A%230001441" target="_blank" >RIV/00027014:_____/11:#0001441 - isvavai.cz</a>

Výsledek na webu

<a href="http://www.vuzv.cz/sites/File/_privat/11081.pdf" target="_blank" >http://www.vuzv.cz/sites/File/_privat/11081.pdf</a>

DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Androgen receptor inhibitor stimulates telomerase activity of pig granulosa cells in vitro

Popis výsledku v původním jazyce

The aim of the study was to investigate the effect of testosterone (T) and dihydrotestosterone (DHT) applied alone or in combination with antiandrogen (flutamide) on proliferation, progesterone secretion and telomerase activity (TA) of pig granulosa cells (GC) derived from small (1-3 mm; SF-GC) and large (5-7 mm; LF-GC) ovarian follicles. Cells were treated with investigated factors for 48 h. 5 alpha-DHT stimulated (P<0.05-0.01) proliferation of SF and LF granulosa cells. Flutamide applied individuallyand in a combination with testosterone and DHT stimulated (P<0.05-0.01) proliferation of pig GC from small and large antral follicles. Flutamide had no effect on progesterone synthesis in small as well as in large follicle GC. Antiandrogen applied individually and in a combination with testosterone and DHT enhanced (P<0.05-0.01) telomerase actitvity in SF-and LF-GC. The results of the study suggest the involvement of androgen receptor in telomerase activity regulation in pig GC and a lin

Název v anglickém jazyce

Androgen receptor inhibitor stimulates telomerase activity of pig granulosa cells in vitro

Popis výsledku anglicky

The aim of the study was to investigate the effect of testosterone (T) and dihydrotestosterone (DHT) applied alone or in combination with antiandrogen (flutamide) on proliferation, progesterone secretion and telomerase activity (TA) of pig granulosa cells (GC) derived from small (1-3 mm; SF-GC) and large (5-7 mm; LF-GC) ovarian follicles. Cells were treated with investigated factors for 48 h. 5 alpha-DHT stimulated (P<0.05-0.01) proliferation of SF and LF granulosa cells. Flutamide applied individuallyand in a combination with testosterone and DHT stimulated (P<0.05-0.01) proliferation of pig GC from small and large antral follicles. Flutamide had no effect on progesterone synthesis in small as well as in large follicle GC. Antiandrogen applied individually and in a combination with testosterone and DHT enhanced (P<0.05-0.01) telomerase actitvity in SF-and LF-GC. The results of the study suggest the involvement of androgen receptor in telomerase activity regulation in pig GC and a lin

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

EB - Genetika a molekulární biologie

OECD FORD obor

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Projekt

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Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2011

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Animal Science Papers and Reports

ISSN

0860-4037

e-ISSN

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Svazek periodika

29

Číslo periodika v rámci svazku

4

Stát vydavatele periodika

PL - Polská republika

Počet stran výsledku

11

Strana od-do

313-323

Kód UT WoS článku

000298158900005

EID výsledku v databázi Scopus

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