Experimentální infekce selat s různým typem a hladinou specifické imunity původcem Actinobacillus pleuropneumonia: imunofenotypická analýza subpopulací lymfocytů v cirkulaci a imunitní tkáni respiračního traktu

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00027162%3A_____%2F05%3A06000034" target="_blank" >RIV/00027162:_____/05:06000034 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Experimental Actinobacillus pleuropneumoniae infection in piglets with different types and levels of specific protection: immunophenotypic analysis of lymphocyte subsets in the circulation and respiratory mucosal lymphoid tissue

Popis výsledku v původním jazyce

In our study we analyzed changes in lymphocyte subset distribution in peripheral blood, bronchoalveolar lavage fluid (BALF) and tracheobronchal lymph nodes (TLN) in non-immune piglets upon a challenge with a high dose of Actinobacillus pleuropneumoniae(APP) and compared the quality of such changes in unprotected piglets with counterparts exhibiting specific immunity mediated by high titers of colostrum-derived APP-specific antibodies and/or a low dose APP infection.APP challenge resulted in a increaseinCD8 negative ?? T-cells in parallel with a reduction in numbers of CD3-CD8low cells in BALF independent of the type and level of immunity. An increase in B-lymphocyte numbers in TLN was another feature accompanying APP infection in all groups. Inpigletswith colostrum-derived APP-specific antibodies, this was associated with higher relative numbers of IgM+CD2+ lymphocytes in TLN, while B-cells with the CD2- surface phenotype apparently expanded in the absence of passive hum. immunity.

Název v anglickém jazyce

Experimental Actinobacillus pleuropneumoniae infection in piglets with different types and levels of specific protection: immunophenotypic analysis of lymphocyte subsets in the circulation and respiratory mucosal lymphoid tissue

Popis výsledku anglicky

In our study we analyzed changes in lymphocyte subset distribution in peripheral blood, bronchoalveolar lavage fluid (BALF) and tracheobronchal lymph nodes (TLN) in non-immune piglets upon a challenge with a high dose of Actinobacillus pleuropneumoniae(APP) and compared the quality of such changes in unprotected piglets with counterparts exhibiting specific immunity mediated by high titers of colostrum-derived APP-specific antibodies and/or a low dose APP infection.APP challenge resulted in a increaseinCD8 negative ?? T-cells in parallel with a reduction in numbers of CD3-CD8low cells in BALF independent of the type and level of immunity. An increase in B-lymphocyte numbers in TLN was another feature accompanying APP infection in all groups. Inpigletswith colostrum-derived APP-specific antibodies, this was associated with higher relative numbers of IgM+CD2+ lymphocytes in TLN, while B-cells with the CD2- surface phenotype apparently expanded in the absence of passive hum. immunity.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

GJ - Choroby a škůdci zvířat, veterinární medicina

OECD FORD obor

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Projekt

<a href="/cs/project/GA524%2F01%2F0290" target="_blank" >GA524/01/0290: Charakteristika imunitní odpovědi respiračního traktu prasat na infekci a imunizaci Actinobacillus pleuropneumoniae</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2005

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Veterinary Immunology and Immunopathology

ISSN

0165-2427

e-ISSN

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Svazek periodika

107

Číslo periodika v rámci svazku

1-2

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

10

Strana od-do

143-152

Kód UT WoS článku

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EID výsledku v databázi Scopus

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