Modeling of Brain Tissue Heating Caused by Direct Cortical Stimulation for Assessing the Risk of Thermal Damage

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064203%3A_____%2F19%3A10394285" target="_blank" >RIV/00064203:_____/19:10394285 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11130/19:10394285 RIV/68407700:21230/19:00328060 RIV/68407700:21460/19:00328060

Výsledek na webu

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=dDRxSOT_Kr" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=dDRxSOT_Kr</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1109/TNSRE.2019.2898253" target="_blank" >10.1109/TNSRE.2019.2898253</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Modeling of Brain Tissue Heating Caused by Direct Cortical Stimulation for Assessing the Risk of Thermal Damage

Popis výsledku v původním jazyce

This paper aims to employ the numerical simulations to assess the risk of cellular damage during the application of a novel paradigm of electrical stimulation mapping (ESM) used in neurosurgery. The core principle of the paradigm is the use of short, high-intensity and high-frequency stimulation pulses. We developed a complex numerical model and performed coupled electro-thermal transient simulations. The model was optimized by incorporating ESM electrodes&apos; resistance obtained during multiple intraoperative measurements and validated by comparing them with the results of temperature distribution measurement acquired by thermal imaging. The risk of heat-induced cellular damage was assessed by applying the Arrhenius equation integral on the computed time-dependent spatial distribution of temperature in the brain tissue. Our results suggest that the impact of the temperature increase during our novel ESM paradigm is thermally non-destructive. The presented simulation results match the previously published thermographic measurement and histopathological examination of the stimulated brain tissue and confirm the safety of the novel ESM.

Název v anglickém jazyce

Modeling of Brain Tissue Heating Caused by Direct Cortical Stimulation for Assessing the Risk of Thermal Damage

Popis výsledku anglicky

This paper aims to employ the numerical simulations to assess the risk of cellular damage during the application of a novel paradigm of electrical stimulation mapping (ESM) used in neurosurgery. The core principle of the paradigm is the use of short, high-intensity and high-frequency stimulation pulses. We developed a complex numerical model and performed coupled electro-thermal transient simulations. The model was optimized by incorporating ESM electrodes&apos; resistance obtained during multiple intraoperative measurements and validated by comparing them with the results of temperature distribution measurement acquired by thermal imaging. The risk of heat-induced cellular damage was assessed by applying the Arrhenius equation integral on the computed time-dependent spatial distribution of temperature in the brain tissue. Our results suggest that the impact of the temperature increase during our novel ESM paradigm is thermally non-destructive. The presented simulation results match the previously published thermographic measurement and histopathological examination of the stimulated brain tissue and confirm the safety of the novel ESM.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30103 - Neurosciences (including psychophysiology)

Projekt

<a href="/cs/project/NV15-30456A" target="_blank" >NV15-30456A: Prevence motorických deficitů po epileptochirurgických výkonech u dětí</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2019

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

IEEE Transactions on Neural Systems and Rehabilitation Engineering

ISSN

1534-4320

e-ISSN

—

Svazek periodika

27

Číslo periodika v rámci svazku

3

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

10

Strana od-do

440-449

Kód UT WoS článku

000462435300012

EID výsledku v databázi Scopus

2-s2.0-85063549956