The Safety Control of the Electrical Stimulation Mapping using numerical simulation

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68407700%3A21230%2F18%3A00324488" target="_blank" >RIV/68407700:21230/18:00324488 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/68407700:21460/18:00324488

Výsledek na webu

<a href="http://dx.doi.org/10.1111/epi.14612" target="_blank" >http://dx.doi.org/10.1111/epi.14612</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1111/epi.14612" target="_blank" >10.1111/epi.14612</a>

Jazyk výsledku

angličtina

Název v původním jazyce

The Safety Control of the Electrical Stimulation Mapping using numerical simulation

Popis výsledku v původním jazyce

The Electrical Stimulation Mapping (ESM) is used for the localization of eloquent cortex and intraoperative monitoring of corticospinal tract. Standard ESM paradigm is ineffective to elicit the motor response in young children group and fails in 20% cases. Therefore, we developed unique ESM protocol based on high intensity, high frequency and a short sequence of stimulation pulses. However, application of the pulses (up to 100 mA) has a potential risk of stimulated tissue overheating. In previous works, we demonstrated the ability to elicit a motor response in all 65 subject (9.2±5.5 years), showed non-destructive temperature effect of ESM using in vivo thermography in 13 subjects (10±4.6 years) supported by after-surgery histopathology in 17 subjects. The complex numerical model simulates cortex tissues, electrodes, perfusion and electrical fields during ESM to reveal the under-surface distribution of temperature with high spatiotemporal resolution. The simulation proved increase of temperature up to 45°C only in thin liquid film humidifying the cortex for <50 ms. The upper cortex layer (pia matter) is heated up to 41°C by heat transfer in total volume <0.005 mm3 and immediately drops to initial temperature before ESM. The probability of tissue damage is close to zero computed using Arrhenius integral. The simulated electrical field and temperature distribution corresponded to in vivo thermography. The numerical simulation has verified the safety of ESM high intense current in accordance with in vivo thermography and histopathology assessment. Discrete short time tissue overheating is not destructive with the minimal hypothetical risk.

Název v anglickém jazyce

The Safety Control of the Electrical Stimulation Mapping using numerical simulation

Popis výsledku anglicky

The Electrical Stimulation Mapping (ESM) is used for the localization of eloquent cortex and intraoperative monitoring of corticospinal tract. Standard ESM paradigm is ineffective to elicit the motor response in young children group and fails in 20% cases. Therefore, we developed unique ESM protocol based on high intensity, high frequency and a short sequence of stimulation pulses. However, application of the pulses (up to 100 mA) has a potential risk of stimulated tissue overheating. In previous works, we demonstrated the ability to elicit a motor response in all 65 subject (9.2±5.5 years), showed non-destructive temperature effect of ESM using in vivo thermography in 13 subjects (10±4.6 years) supported by after-surgery histopathology in 17 subjects. The complex numerical model simulates cortex tissues, electrodes, perfusion and electrical fields during ESM to reveal the under-surface distribution of temperature with high spatiotemporal resolution. The simulation proved increase of temperature up to 45°C only in thin liquid film humidifying the cortex for <50 ms. The upper cortex layer (pia matter) is heated up to 41°C by heat transfer in total volume <0.005 mm3 and immediately drops to initial temperature before ESM. The probability of tissue damage is close to zero computed using Arrhenius integral. The simulated electrical field and temperature distribution corresponded to in vivo thermography. The numerical simulation has verified the safety of ESM high intense current in accordance with in vivo thermography and histopathology assessment. Discrete short time tissue overheating is not destructive with the minimal hypothetical risk.

Druh

O - Ostatní výsledky

CEP obor

—

OECD FORD obor

20601 - Medical engineering

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2018

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů