Increased proportions of gamma delta T lymphocytes in atypical SCID associate with disease manifestations

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064203%3A_____%2F19%3A10394340" target="_blank" >RIV/00064203:_____/19:10394340 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11130/19:10394340

Výsledek na webu

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=7DQA6WXkb7" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=7DQA6WXkb7</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.clim.2018.11.006" target="_blank" >10.1016/j.clim.2018.11.006</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Increased proportions of gamma delta T lymphocytes in atypical SCID associate with disease manifestations

Popis výsledku v původním jazyce

Severe combined immunodeficiencies (SCID) comprise a group of genetic diseases characterized by abrogated development of T lymphocytes. In some case reports of atypical SCID patients elevated proportions of gamma delta T lymphocytes have been reported. However, it is unknown whether these gamma delta T cells modulate or reflect the patient&apos;s clinical phenotype. We investigated the frequency of elevated gamma delta T cell proportions and associations with clinical disease manifestations in a cohort of 76 atypical SCID patients. Increased proportions of gamma delta T lymphocytes were present in approximately 600/0 of these patients. Furthermore, we identified positive correlations between elevated proportions of gamma delta T cells and the occurrence of CMV infections and autoimmune cytopenias. We discuss that CMV infections might trigger an expansion of gamma delta T lymphocytes, which could drive the development of autoimmune cytopenias. We advocate that atypical SCID patients should be screened for elevated proportions of gamma delta T lymphocytes, CMV infection and autoimmune cytopenias.

Název v anglickém jazyce

Increased proportions of gamma delta T lymphocytes in atypical SCID associate with disease manifestations

Popis výsledku anglicky

Severe combined immunodeficiencies (SCID) comprise a group of genetic diseases characterized by abrogated development of T lymphocytes. In some case reports of atypical SCID patients elevated proportions of gamma delta T lymphocytes have been reported. However, it is unknown whether these gamma delta T cells modulate or reflect the patient&apos;s clinical phenotype. We investigated the frequency of elevated gamma delta T cell proportions and associations with clinical disease manifestations in a cohort of 76 atypical SCID patients. Increased proportions of gamma delta T lymphocytes were present in approximately 600/0 of these patients. Furthermore, we identified positive correlations between elevated proportions of gamma delta T cells and the occurrence of CMV infections and autoimmune cytopenias. We discuss that CMV infections might trigger an expansion of gamma delta T lymphocytes, which could drive the development of autoimmune cytopenias. We advocate that atypical SCID patients should be screened for elevated proportions of gamma delta T lymphocytes, CMV infection and autoimmune cytopenias.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30204 - Oncology

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2019

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Clinical Immunology

ISSN

1521-6616

e-ISSN

—

Svazek periodika

201

Číslo periodika v rámci svazku

April

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

5

Strana od-do

30-34

Kód UT WoS článku

000463692100005

EID výsledku v databázi Scopus

2-s2.0-85062236926