IgE recognition patterns in peanut allergy are age dependent: perspectives of the EuroPrevall study

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064211%3A_____%2F15%3A%230000456" target="_blank" >RIV/00064211:_____/15:#0000456 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11140/15:10326601

Výsledek na webu

<a href="http://onlinelibrary.wiley.com/doi/10.1111/all.12574/abstract" target="_blank" >http://onlinelibrary.wiley.com/doi/10.1111/all.12574/abstract</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1111/all.12574" target="_blank" >10.1111/all.12574</a>

Jazyk výsledku

angličtina

Název v původním jazyce

IgE recognition patterns in peanut allergy are age dependent: perspectives of the EuroPrevall study

Popis výsledku v původním jazyce

Background: We tested the hypothesis that specific molecular sensitization patterns correlate with the clinical data/manifestation in a European peanut-allergic population characterized under a common protocol.Methods: Sixty-eight peanut-allergic subjects and 82 tolerant controls from 11 European countries were included. Allergy to peanut and lowest symptom-eliciting dose was established by double-blind placebo-controlled food challenge in all but anaphylactic subjects. Information of early or late (before or after 14 years of age) onset of peanut allergy was obtained from standardized questionnaires. IgE to peanut allergens rAra h 1-3, 6, 8-9, profilin and CCD was determined using ImmunoCAP.Results: Seventy-eight percent of peanut allergics were sensitized to peanut extract and 90% to at least one peanut component. rAra h 2 was the sole major allergen for the peanut-allergic population. Geographical differences were observed for rAra h 8 and rAra h 9, which were major allergens for central/western and southern Europeans, respectively. Sensitization to rAra h 1 and 2 was exclusively observed in early-onset peanut allergy. Peanut-tolerant subjects were frequently sensitized to rAra h 8 or 9 but not to storage proteins. Sensitization to Ara h 2 >= 1.0 kU(A)/l conferred a 97% probability for a systemic reaction (P = 0.0002). Logistic regression revealed a significant influence of peanut extract sensitization and region on the occurrence of systemic reactions (P = 0.0185 and P = 0.0436, respectively).Conclusion: Sensitization to Ara h 1, 2 and 3 is usually acquired in childhood. IgE to Ara h 2 >= 1.0 kU(A)/l is significantly associated with the development of systemic reactions to peanut.

Název v anglickém jazyce

IgE recognition patterns in peanut allergy are age dependent: perspectives of the EuroPrevall study

Popis výsledku anglicky

Background: We tested the hypothesis that specific molecular sensitization patterns correlate with the clinical data/manifestation in a European peanut-allergic population characterized under a common protocol.Methods: Sixty-eight peanut-allergic subjects and 82 tolerant controls from 11 European countries were included. Allergy to peanut and lowest symptom-eliciting dose was established by double-blind placebo-controlled food challenge in all but anaphylactic subjects. Information of early or late (before or after 14 years of age) onset of peanut allergy was obtained from standardized questionnaires. IgE to peanut allergens rAra h 1-3, 6, 8-9, profilin and CCD was determined using ImmunoCAP.Results: Seventy-eight percent of peanut allergics were sensitized to peanut extract and 90% to at least one peanut component. rAra h 2 was the sole major allergen for the peanut-allergic population. Geographical differences were observed for rAra h 8 and rAra h 9, which were major allergens for central/western and southern Europeans, respectively. Sensitization to rAra h 1 and 2 was exclusively observed in early-onset peanut allergy. Peanut-tolerant subjects were frequently sensitized to rAra h 8 or 9 but not to storage proteins. Sensitization to Ara h 2 >= 1.0 kU(A)/l conferred a 97% probability for a systemic reaction (P = 0.0002). Logistic regression revealed a significant influence of peanut extract sensitization and region on the occurrence of systemic reactions (P = 0.0185 and P = 0.0436, respectively).Conclusion: Sensitization to Ara h 1, 2 and 3 is usually acquired in childhood. IgE to Ara h 2 >= 1.0 kU(A)/l is significantly associated with the development of systemic reactions to peanut.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FN - Epidemiologie, infekční nemoci a klinická imunologie

OECD FORD obor

—

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

ALLERGY

ISSN

0105-4538

e-ISSN

—

Svazek periodika

70

Číslo periodika v rámci svazku

4

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

17

Strana od-do

391-407

Kód UT WoS článku

000351654200007

EID výsledku v databázi Scopus

—