Leptin Deficiency Promotes Central Sleep Apnea in Patients With Heart Failure

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F14%3A00060944" target="_blank" >RIV/00159816:_____/14:00060944 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1378/chest.12-2914" target="_blank" >http://dx.doi.org/10.1378/chest.12-2914</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1378/chest.12-2914" target="_blank" >10.1378/chest.12-2914</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Leptin Deficiency Promotes Central Sleep Apnea in Patients With Heart Failure

Popis výsledku v původním jazyce

Background: Leptin-deficient animals hyperventilate. Leptin expression by adipocytes is attenuated by atrial natriuretic peptide (ANP). Increased circulating natriuretic peptides (NPs) are associated with an increased risk of central sleep apnea (CSA). This study tested whether serum leptin concentration is inversely correlated to NP concentration and decreased in patients with heart failure (HF) and CSA. Methods: Subjects with HF (N = 29) were studied by measuring leptin, NPs, CO2 chemosensitivity (Delta minute ventilation [(V) over dotE]/Delta partial pressure of end-tidal CO2 [PETCO2]), and ventilatory efficiency ((V) over dotE/CO2 output [(V) over dotO(2)]) and were classified as CSA or no sleep-disordered breathing by polysomnography. CSA was defined as a central apnea-hypopnea index >= 15. The Student t test, Mann-Whitney U test, and logistic regression were used for analysis, and data were summarized as mean +/- SD; P < .05 was considered significant. Results: Subjects with CSA

Název v anglickém jazyce

Leptin Deficiency Promotes Central Sleep Apnea in Patients With Heart Failure

Popis výsledku anglicky

Background: Leptin-deficient animals hyperventilate. Leptin expression by adipocytes is attenuated by atrial natriuretic peptide (ANP). Increased circulating natriuretic peptides (NPs) are associated with an increased risk of central sleep apnea (CSA). This study tested whether serum leptin concentration is inversely correlated to NP concentration and decreased in patients with heart failure (HF) and CSA. Methods: Subjects with HF (N = 29) were studied by measuring leptin, NPs, CO2 chemosensitivity (Delta minute ventilation [(V) over dotE]/Delta partial pressure of end-tidal CO2 [PETCO2]), and ventilatory efficiency ((V) over dotE/CO2 output [(V) over dotO(2)]) and were classified as CSA or no sleep-disordered breathing by polysomnography. CSA was defined as a central apnea-hypopnea index >= 15. The Student t test, Mann-Whitney U test, and logistic regression were used for analysis, and data were summarized as mean +/- SD; P < .05 was considered significant. Results: Subjects with CSA

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FA - Kardiovaskulární nemoci včetně kardiochirurgie

OECD FORD obor

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Projekt

<a href="/cs/project/ED1.100%2F02%2F0123" target="_blank" >ED1.100/02/0123: Fakultní nemocnice u sv. Anny v Brně - Mezinárodní centrum klinického výzkumu (FNUSA - ICRC)</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2014

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Chest

ISSN

0012-3692

e-ISSN

—

Svazek periodika

145

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

7

Strana od-do

72-78

Kód UT WoS článku

000329966300020

EID výsledku v databázi Scopus

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