Exercise End-Tidal Carbon Dioxide Predicts Central Sleep Apnea in Heart Failure Patients

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F15%3A00062593" target="_blank" >RIV/00159816:_____/15:00062593 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1378/chest.14-2114" target="_blank" >http://dx.doi.org/10.1378/chest.14-2114</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1378/chest.14-2114" target="_blank" >10.1378/chest.14-2114</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Exercise End-Tidal Carbon Dioxide Predicts Central Sleep Apnea in Heart Failure Patients

Popis výsledku v původním jazyce

Increased carbon dioxide (CO2) chemosensitivity and augmented exercise ventilation are characteristic of heart failure (HF) patients with central sleep apnea (CSA). The aim of this study was to test the hypothesis that decreased end-tidal CO2 by cardiopulmonary exercise testing predicts CSA in HF patients. METHODS: Consecutive ambulatory NYHA II-III HF patients were prospectively evaluated by CO2 chemosensitivity by rebreathe, cardiopulmonary exercise testing and polysomnography (PSG). Subjects were classified as either CSA (n=20) or no sleep apnea (n=13) by PSG; a central apnea-hypopnea index GREATER-THAN OR EQUAL TO5 defined CSA. Subgroups were compared by t-test or Mann Whitney test and data summarized as mean +- SD; p<0.05 was considered significant. RESULTS: At rest, subjects with CSA had higher CO2 chemosensitivity (INCREMENT V.E/INCREMENT PETCO2) (2.3+-1.0 vs. 1.6+-0.4L/min/mmHg; p=0.02), minute ventilation (V.E) (15+-7 vs. 10+-3L/min; p=0.02) and lower end-tidal CO2 (PETCO2) (3

Název v anglickém jazyce

Exercise End-Tidal Carbon Dioxide Predicts Central Sleep Apnea in Heart Failure Patients

Popis výsledku anglicky

Increased carbon dioxide (CO2) chemosensitivity and augmented exercise ventilation are characteristic of heart failure (HF) patients with central sleep apnea (CSA). The aim of this study was to test the hypothesis that decreased end-tidal CO2 by cardiopulmonary exercise testing predicts CSA in HF patients. METHODS: Consecutive ambulatory NYHA II-III HF patients were prospectively evaluated by CO2 chemosensitivity by rebreathe, cardiopulmonary exercise testing and polysomnography (PSG). Subjects were classified as either CSA (n=20) or no sleep apnea (n=13) by PSG; a central apnea-hypopnea index GREATER-THAN OR EQUAL TO5 defined CSA. Subgroups were compared by t-test or Mann Whitney test and data summarized as mean +- SD; p<0.05 was considered significant. RESULTS: At rest, subjects with CSA had higher CO2 chemosensitivity (INCREMENT V.E/INCREMENT PETCO2) (2.3+-1.0 vs. 1.6+-0.4L/min/mmHg; p=0.02), minute ventilation (V.E) (15+-7 vs. 10+-3L/min; p=0.02) and lower end-tidal CO2 (PETCO2) (3

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FA - Kardiovaskulární nemoci včetně kardiochirurgie

OECD FORD obor

—

Projekt

<a href="/cs/project/ED1.100%2F02%2F0123" target="_blank" >ED1.100/02/0123: Fakultní nemocnice u sv. Anny v Brně - Mezinárodní centrum klinického výzkumu (FNUSA - ICRC)</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Chest

ISSN

0012-3692

e-ISSN

—

Svazek periodika

147

Číslo periodika v rámci svazku

6

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

12

Strana od-do

1566-1573

Kód UT WoS článku

000355837900037

EID výsledku v databázi Scopus

—