Modulation of Ventilatory Reflex Control by Cardiac Resynchronization Therapy

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F15%3A00061636" target="_blank" >RIV/00159816:_____/15:00061636 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1016/j.cardfail.2014.12.013" target="_blank" >http://dx.doi.org/10.1016/j.cardfail.2014.12.013</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.cardfail.2014.12.013" target="_blank" >10.1016/j.cardfail.2014.12.013</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Modulation of Ventilatory Reflex Control by Cardiac Resynchronization Therapy

Popis výsledku v původním jazyce

Heart failure (HF) is characterized by heightened sensitivity of the CO2 chemoreflex and the ergoreflex which promote increased ventilatory drive manifest as increased minute ventilation per volume of expired CO2 (VE/VCO2). The aims of this study were toevaluate the effects of cardiac resynchronization therapy (CRT) on carbon dioxide (CO2) chemosensitivity and the arterial CO2 setpoint. METHODS AND RESULTS: Consecutive HF patients (n=35) who underwent clinically-indicated CRT were investigated by cardiopulmonary exercise testing and CO2 chemosensitivity by a rebreathe method before and 4-6 months post-CRT. Pre- and post-CRT measures were compared by either paired t-test or Wilcoxon test. Decreased peak VE/VCO2 (44+-10 vs. 40+-8; p<0.01), CO2 chemosensitivity (2.2+-1.1 vs. 1.7+-0.8 L/min/mmHg; p=0.04) and increased peak end-tidal CO2 (29+-5 vs. 31+-5 mmHg; p<0.01) were also observed post-CRT. Multivariate analysis adjusted for age and gender showed the decrease of peak VE/VCO2 from pre

Název v anglickém jazyce

Modulation of Ventilatory Reflex Control by Cardiac Resynchronization Therapy

Popis výsledku anglicky

Heart failure (HF) is characterized by heightened sensitivity of the CO2 chemoreflex and the ergoreflex which promote increased ventilatory drive manifest as increased minute ventilation per volume of expired CO2 (VE/VCO2). The aims of this study were toevaluate the effects of cardiac resynchronization therapy (CRT) on carbon dioxide (CO2) chemosensitivity and the arterial CO2 setpoint. METHODS AND RESULTS: Consecutive HF patients (n=35) who underwent clinically-indicated CRT were investigated by cardiopulmonary exercise testing and CO2 chemosensitivity by a rebreathe method before and 4-6 months post-CRT. Pre- and post-CRT measures were compared by either paired t-test or Wilcoxon test. Decreased peak VE/VCO2 (44+-10 vs. 40+-8; p<0.01), CO2 chemosensitivity (2.2+-1.1 vs. 1.7+-0.8 L/min/mmHg; p=0.04) and increased peak end-tidal CO2 (29+-5 vs. 31+-5 mmHg; p<0.01) were also observed post-CRT. Multivariate analysis adjusted for age and gender showed the decrease of peak VE/VCO2 from pre

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FA - Kardiovaskulární nemoci včetně kardiochirurgie

OECD FORD obor

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Projekt

<a href="/cs/project/ED1.100%2F02%2F0123" target="_blank" >ED1.100/02/0123: Fakultní nemocnice u sv. Anny v Brně - Mezinárodní centrum klinického výzkumu (FNUSA - ICRC)</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Cardiac Failure

ISSN

1071-9164

e-ISSN

—

Svazek periodika

21

Číslo periodika v rámci svazku

5

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

12

Strana od-do

367-373

Kód UT WoS článku

000354420600002

EID výsledku v databázi Scopus

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