Variability assessment of manual segmentations of ischemic lesion volume on 24-h non-contrast CT

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F22%3A00075176" target="_blank" >RIV/00159816:_____/22:00075176 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11150/22:10444214 RIV/00216224:14110/22:00125374

Výsledek na webu

<a href="https://link.springer.com/article/10.1007%2Fs00234-021-02855-z" target="_blank" >https://link.springer.com/article/10.1007%2Fs00234-021-02855-z</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s00234-021-02855-z" target="_blank" >10.1007/s00234-021-02855-z</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Variability assessment of manual segmentations of ischemic lesion volume on 24-h non-contrast CT

Popis výsledku v původním jazyce

Purpose Infarct lesion volume (ILV) may serve as an imaging biomarker for clinical outcomes in the early post-treatment stage in patients with acute ischemic stroke. The aim of this study was to evaluate the inter- and intra-rater reliability of manual segmentation of ILV on follow-up non-contrast CT (NCCT) scans. Methods Fifty patients from the Prove-IT study were randomly selected for this analysis. Three raters manually segmented ILV on 24-h NCCT scans, slice by slice, three times. The reference standard for ILV was generated by the Simultaneous Truth And Performance Level estimation (STAPLE) algorithm. Intra- and inter-rater reliability was evaluated, using metrics of intraclass correlation coefficient (ICC) regarding lesion volume and the Dice similarity coefficient (DSC). Results Median age of the 50 subjects included was 74.5 years (interquartile range [IQR] 67-80), 54% were women, median baseline National Institutes of Health Stroke Scale was 18 (IQR 11-22), median baseline ASPECTS was 9 (IQR 6-10). The mean reference standard ILV was 92.5 ml (standard deviation (SD) +/- 100.9 ml). The manually segmented ILV ranged from 88.2 +/- 91.5 to 135.5 +/- 119.9 ml (means referring to the variation between readers, SD within readers). Inter-rater ICC was 0.83 (95%CI: 0.76-0.88); intra-rater ICC ranged from 0.85 (95%CI: 0.72-0.92) to 0.95 (95%CI: 0.91-0.97). The mean DSC among the three readers ranged from 65.5 +/- 22.9 to 76.4 +/- 17.1% and the mean overall DSC was 72.8 +/- 23.0%. Conclusion Manual ILV measurements on follow-up CT scans are reliable to measure the radiological outcome despite some variability.

Název v anglickém jazyce

Variability assessment of manual segmentations of ischemic lesion volume on 24-h non-contrast CT

Popis výsledku anglicky

Purpose Infarct lesion volume (ILV) may serve as an imaging biomarker for clinical outcomes in the early post-treatment stage in patients with acute ischemic stroke. The aim of this study was to evaluate the inter- and intra-rater reliability of manual segmentation of ILV on follow-up non-contrast CT (NCCT) scans. Methods Fifty patients from the Prove-IT study were randomly selected for this analysis. Three raters manually segmented ILV on 24-h NCCT scans, slice by slice, three times. The reference standard for ILV was generated by the Simultaneous Truth And Performance Level estimation (STAPLE) algorithm. Intra- and inter-rater reliability was evaluated, using metrics of intraclass correlation coefficient (ICC) regarding lesion volume and the Dice similarity coefficient (DSC). Results Median age of the 50 subjects included was 74.5 years (interquartile range [IQR] 67-80), 54% were women, median baseline National Institutes of Health Stroke Scale was 18 (IQR 11-22), median baseline ASPECTS was 9 (IQR 6-10). The mean reference standard ILV was 92.5 ml (standard deviation (SD) +/- 100.9 ml). The manually segmented ILV ranged from 88.2 +/- 91.5 to 135.5 +/- 119.9 ml (means referring to the variation between readers, SD within readers). Inter-rater ICC was 0.83 (95%CI: 0.76-0.88); intra-rater ICC ranged from 0.85 (95%CI: 0.72-0.92) to 0.95 (95%CI: 0.91-0.97). The mean DSC among the three readers ranged from 65.5 +/- 22.9 to 76.4 +/- 17.1% and the mean overall DSC was 72.8 +/- 23.0%. Conclusion Manual ILV measurements on follow-up CT scans are reliable to measure the radiological outcome despite some variability.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

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OECD FORD obor

30100 - Basic medicine

Projekt

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Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2022

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Neuroradiology

ISSN

0028-3940

e-ISSN

1432-1920

Svazek periodika

64

Číslo periodika v rámci svazku

6

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

9

Strana od-do

1165-1173

Kód UT WoS článku

000721656300003

EID výsledku v databázi Scopus

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